Translational Methods for Multiple Sclerosis Research (Neuromethods)

This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements. Preface... Table of Contents... Contributing Authors... Part I Pathophysiological Fingerprints of MS and Related Neuroimmunological Disorders 1. Pathophysiological Bases of Autoimmune Initiated/Mediated Neurodegeneration Hans Lassmann 2. Translational Animal Models for MS and Related Neuroimmunological Disorders Felix M. Glaser and Tobias Ruck 3. White Matter Pathology Angela Radetz and Sergiu Groppa 4. Pathophysiology of Grey Matter Affection in MS Gabriel Gonzalez-Escamilla and Dumitru Ciolac 5. Translational Characterization of Glia Role in Multiple Sclerosis Dumitru Ciolac, Stanislav Groppa, and Gabriel Gonzalez-Escamilla 6. Translational Value of CSF and Blood Markers of Autoimmunity and Neurodegeneration Timo Uphaus and Stefan Bittner Part II Animal Models of Neuroinflammation 7. Spontaneous Mouse Models of Neuroinflammation Shin-Young Na and Gurumoorthy Krishnamoorthy 8. Chronic Progressive Models Maren Lindner, Ann-Katrin Fleck, and Luisa Klotz 9. Electrophysiological Measurements of Brain Network Characterization in Rodents Manuela Cerina, Luca Fazio, and Sven G. Meuth Part III Translation of Functional Domain Abnormalities from Human to Mice 10. Translation of Functional Domain Abnormalities from Human to Mouse Motor System Muthuraman Muthuraman, Dumitru Ciolac, and Venkata Chaitanya Chirumamilla 11. Characterization of the Somatosensory System Carsten H. Wolters, Marios Antonakakis, Asad Khan, Maria Carla Piastra, and Johannes Vorwerk 12. Translational Research in Neuroimmunology: Cognition Maren Person and Miriam Becke 13. Models for Assessing Anxiety and Depression in Multiple Sclerosis: From Mouse to Man Erik Ellwardt and Dirk Luchtman Part IV Exploring Translational Paths in MS with Brain Imaging: Small Animal to Human Imaging Tools 14. Human Structural MRI Menno M. Schoonheim 15. Human Functional MRI Paolo Preziosa, Paola Valsasina, Massimo Filippi, and Maria A. Rocca 16. Functional Studies in Rodents Lydia Wachsmuth and Cornelius Faber 17. Non-Invasive Electrophysiology Matthias Grothe Part V Translational View on Therapeutic Strategies 18. Targeting Acute Inflammation Felix Lssi 19. Translational Aspects of Immunotherapeutic Targets in MS Vinzenz Fleischer 20. Therapeutic Strategies to Potentially Cure Multiple Sclerosis: Insights into the Mechanisms of Autologous Hematopoietic Stem Cell Transplantation Leonie Rolfes and Marc Pawlitzki 21. Symptomatic MS Therapy Julia Krmer and Sven G. Meuth