Description
This text is aimed at defining the current concepts that define trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It will serve as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader will have full understanding of the tests that are used to study trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications are reviewed in detail. Trauma Induced Coagulopathy will also be a valuable source for quick reference to the clinician that is faced with specific clinical challenges when managing coagulopathy. Ernest E. Moore, MD is Editor, Journal of Trauma and Acute Care Surgery (LWW) Trauma Induced Coagulopathy Eduardo Gonzalez, Hunter B. Moore, Ernest E. Moore Table of Contents Foreword Kenneth Mann Preface Ernest E. Moore, Hunter B. Moore, Eduardo Gonzalez Introduction: Historical Perspective: History of Trauma Induced Coagulopathy Ernest E. Moore, Eduardo Gonzalez, Hunter B. Moore Part 1: Physiology of Hemostasis Chapter 1: Cell-Mediated Hemostasis Maureane Hoffman Chapter 2: Antithrombin Contributions to Physiological Hemostasis and Thrombosis Prevention, and its Dysregulation in Trauma and TIC Susan C. Bock Chapter 3: Physiology of Hemostasis: Plasmin-antiplasmin system Nicola J Mutch, Nuala A Booth Part 2: Pathogenesis of Trauma Induced Coagulopathy Chapter 4: Thrombin Formation Shekhar Kumar, Sriram Krishnaswamy Chapter 5: Fibrinogen Eduardo Gonzalez, Ernest E. Moore, Hunter B. Moore Chapter 6: Activated Protein C Mitchell Jay Cohen, Benjamin M. Howard Chapter 7: Pathogenesis of Trauma Induced Coagulopathy: The Endothelium Pr I. Johansson, Sisse R. Ostrowski Chapter 8: Platelets Scott L. Diamond Chapter 9: Fibrinolysis Hunter B. Moore, Ernest E. Moore, Eduardo Gonzalez Chapter 10: Neutrophils, Inflammation and Innate Immunity in Trauma-Induced Coagulopathy Christopher D. Barrett, Michael B. Yaffe Chapter 11: DAMPs: Damage-Associated Molecular Pattern Molecules in Hemostasis Charles T. Esmon
