Description
Chapter 1: The Molecular Pathology of Neurodegenerative And Psychiatric Disorders Alzheimer’s Disease Parkinson’s Disease Multiple Sclerosis Psychiatric Disorders Chapter 2: Receptor Tyrosine Kinases (RTKs): An Overview Receptor tyrosine kinases (RTKs) Families and Subfamilies Receptor tyrosine kinase (RTKs) signaling Biological expression and functions in the brain and other tissues Roles of RTKs in several diseases Molecular mechanisms of receptor tyrosine kinase-mediated neurodegeneration Current status of receptor tyrosine kinases inhibitors as therapeutic targets Chapter 3: Roles of TRK Receptors, Tyrosine Kinase Receptors for Neurotrophins in the Developing CNS Intracellular signaling via Trk tyrosine kinase receptors Role of brain-derived neurotrophic factors/tropomyosin receptor kinase B (BDNF/TrkB) system in synaptic function Synaptic proteins and neurotrophins/receptors system Role of tropomyosin receptor kinase (TrkR) and P75 neurotrophin receptors (p75NTR) in neurogenesis Aging and neurotrophins receptors Neurotrophins/Receptors signaling in Alzheimer’s disease Chapter 4: Role Of Receptor Tyrosine Kinase In The Central Nervous System In Health And Disease 1. Structure of receptor tyrosine kinases (RTKs) 2. Activation of RTKs in a healthy central nervous system (CNS) 3. Classification of RTKs 4. Role of RTKs in healthy CNS 5. Expression and activation of RTK in neurodegenerative disorders 6. Expression and activation of RTK in Psychiatric disorders 7. Concluding remarks Chapter 5: Growth Factors and Their Receptors: Multitasking Functionality in Health and Disease Neurodegenerative Diseases Management of Psychiatric Disorders in Relations with Neurodegenerative diseases Role of Receptor Tyrosine Kinase (RTK) in cell signaling Activation of Receptor tyrosine kinase (RTK) Major Classes of Growth Factors Acting in the Nervous System Growth Factor as Therapeutic Strategies in NDDs: Future Prospects Chapter 6: Regulation of Receptor Tyrosine Kinase Gene Expression Receptor tyrosine kinase genes Regulation of receptor tyrosine kinase gene expression Mechanism of receptor tyrosine kinase activation Regulation of receptor tyrosine kinase activity Downstream effectors of RTKs regulating the pathophysiology of neurodegenerative diseases and Psychiatric disorders Chapter 7: Role Of Receptor Tyrosine Kinases (RTKs) In Neurodegenerative Disorders Role of receptor tyrosine kinases (RTKs) in Alzheimer’s disease Role of receptor tyrosine kinase (RTKs) in Parkinson’s disease (PD) Role of RTKs in Amyotrophic lateral sclerosis (ALS) Role of RTKs in Multiple sclerosis Chapter 8: Receptor Tyrosine Kinase Signaling in Neurodegenerative Disorders Rearranged during transfection (RET) receptors Epidermal Growth Factor Receptor (EGFR; HER or ErbB) Vascular endothelial growth factor receptors (VEGFRs) Tyro3, Axl, and Mertk (TAM receptors) Tropomyosin receptor kinase (Trk) receptors Chapter 9: Receptor Tyrosine Kinases in Major Depressive Disorder Major depressive disorder Dysregulation of Neuregulin-1/ErbB pathway in MDD Role of tropomyosin kinase receptor B (TrkB) in MDD Role of Fibroblast growth factor receptors (FGFRs) in MDD Role of Ephrin (Eph) receptors in MDD Chapter 10: Repositioning of Receptor Tyrosine Kinase Inhibitors: From Cancer to Neurodegenerative And Psychiatric Disorders Neurodegenerative disorders (NDD) Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis Multiple sclerosis (MS) Psychiatric disorders Major depressive disorder (MDD) Schizophrenia (SCZ) Chapter 11: Protein Kinase Inhibitors as Therapeutics in Neurodegenerative and Psychiatric Disorders: Progress, Challenges, and Recommendations Introduction The clinical experience Multispecific inhibitors Towards oligospecific inhibitors Towards dual/monospecific inhibitors Concluding Remarks
