Description
The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sleep is regulated. Consequently narcolepsy now receives a great deal of attention from both clinicians and scientists throughout the world. Narcolepsy: Pathophysiology, Diagnosis, and Treatment not only offers an engaging and comprehensive treatment of a fascinating disorder but also includes a DVD that offers a unique and large collection of movies displaying the symptoms of narcolepsy in people and animals. Written by some of the best experts in the field, the book focuses on the pathophysiology of the problem and also provides critical, up-to-date insights on the key clinical issues: how to diagnose the disorder, how to treat it, and how to best manage psychosocial problems. The first and only guide to span the latest advances in narcolepsy, this reference provides sections in etiology, neurochemistry, the role of the hypocretins in sleep-wake regulation, animal models in narcolepsy, the key role of the hypothalamus, REM-sleep dysregulation, diagnosis and classification, and treatment. Compiled by an international group of more than 30 authors, Narcolepsy: Pathophysiology, Diagnosis, and Treatment is an indispensable resource for all clinicians and scientists with an interest in narcolepsy. Christian R. Baumann, MD University Hospital of Zurich, Switzerland Claudio L. Bassetti, MD University Hospital of Zurich, Switzerland Thomas E. Scammell, MD Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA 1. ETIOLOGY OF NARCOLEPSY Etiology and genetics of human narcolepsy Emmanuel Mignot Narcolepsy: autoimmunity or secondary to infection? Adriano Fontana, Heidemarie Gast, Thomas Birchler Is narcolepsy a neurodegenerative disorder? Christelle Peyron 2. NEUROCHEMISTRY OF NARCOLEPSY The roles of hypocretin/orexin in narcolepsy, Parkinson’s disease, and normal behaviour Jerome Siegel Histamine in narcolepsy and excessive daytime sleepiness Seiji Nishino Dopaminergic substrates underlying hypersomnia, sleepiness, and REM sleep expression David B. Rye, Amanda A.H. Freeman The serotoninergic system in sleep and narcolepsy Chlo Alexandre, Thomas E. Scammell Sleep homeostasis, adenosine, caffeine, and narcolepsy Hans-Peter Landolt Prostaglandin D2: an endogenous somnogen Yoshihiro Urade, Osamu Hayaishi 3. THE ROLE OF THE HYPOCRETINS IN SLEEP-WAKE REGULATION The neurobiology of sleep-wake systems: an overview Pierre-Herv Luppi, Patrice Fort The hypocretins/orexins: master regulators of arousal and hyperarousal Matthew E. Carter, Antoine Adamantidis, Luis de Lecea Optogenetic probing of hypocretin/orexin regulation of wakefulness Antoine Adamantidis, Luis de Lecea Hypocretin/orexin receptor functions in mesopontine systems regulating sleep, arousal and cataplexy Christopher S. Leonard, Mike Kalogiannis, Kristi A. Kohlmeier Afferent control of the hypocretin/orexin neurons Thomas S. Kilduff, Junko Hara, Takeshi Sakurai, Xinmin Xie The neural basis of sleepiness in narcoleptic mice Thomas E. Scammell, Chlo Alexandre Mathematical models of narcolepsy Cecilia Diniz Behn 4. THE KEY ROLE OF THE HYPOTHALAMUS The hypothalamus and its functions Giovanna Zoccoli, Roberto Amici, Alessandro Silvani The prehistory of orexin/hypocretin and melanin-concentrating hormone neurons of the lateral hypothalamus Clifford B. Saper Metabolic influence on the hypocretin/orexin neurons Denis Burdakov Endocrine abnormalities in narcolepsy Thomas Pollmcher. Marietta Keckeis, Andreas Schuld Appetite and obesity Alice Engel, Norbert Dahmen 5. REWARD, ADDICTION, EMOTIONS AND THE HYPOCRETIN SYSTEM Effects of orexin/hypocretin on ventral tegmental area dopamine neurons: an emerging role in addiction Stephanie L. Borgland Orexin/hypocretin, drug addiction, and narcolepsy Ralph J. DiLeone, Maysa Sarhan, Ruth Sharf Emotional processing in narcolepsy Sophie Schwartz Depression in narcolepsy Michael Lutter 6. REM SLEEP DYSREGULATION AND MOTOR ABNORMALITIES IN NARCOLEPSY The clinical features of cataplexy Sebastiaan Overeem Parasomnias in narcolepsy with cataplexy Yves Dauvilliers, Rgis Lopez The motor system and narcolepsy: Periodic leg movements and restless leg syndrome Luigi Ferini Strambi 7. THE BORDERLANDS OF NARCOLEPSY Spectrum of narcolepsy Claudio Bassetti Secondary narcolepsy Philipp O. Valko, Rositsa Poryazova Posttraumatic narcolepsy Christian R. Baumann, Rositsa Poryazova The hypocretin/orexin system and sleepiness in Parkinson’s disease Rolf Fronczek Idiopathic hypersomnia Ramin Khatami 8. THE DIAGNOSIS OF NARCOLEPSY AND THE ASSESSMENT OF FITNESS TO DRIVE Current diagnostic criteria of adult narcolepsy Alex Iranzo The arguments for standardized diagnostic procedures Geert Mayer Fitness to drive in narcolepsy Johannes Mathis 9. TREATMENT OF NARCOLEPSY Treatment of narcolepsy Gert Jan Lammers Treatment of narcolepsy in the childMichel Lecendreux
