Description
A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer’s and Parkinson’s. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors. Ch. 1: On the Discovery of the Nicotinic Acetylcholine Receptor Channel Richard Martindale, Robin A.J. Lester, Ph.D., Ch. 2: Molecular Structure and Gating Steen E. Pedersen, Ph.D Ch. 3: Molecular Underpinnings of Neuronal Nicotinic Acetylcholine Receptor Expression Michael D. Scofield, Ph.D., Paul D. Gardner, Ph.D., Ch. 4: Presynaptic Nicotinic Receptors: Subtypes and Function Michael J. Marks, B.S., M.S., Ph.D., Sharon R. Grady, Ph.D. Tristan D. McClure-Begley, Ph.D. Heidi C. O’Neill, Ph.D., Cristian A. Zambrano, Ph.D. Ch. 5: Functional Distribution and Regulation of Neuronal Nicotinic Acetylcholine Receptors in the Mammalian Brain Jerrel L. Yakel, Ph.D. Ch. 6: Nicotinic Signaling in Development Catarina C. Fernandes, Ph.D. Adrian F. Lozada, Ph.D. Darwin K. Berg, Ph.D. Ch. 7: Presynaptic Nicotinic Acetylcholine Receptors & The Modulation Of Circuit Excitability Chongbo Zhong, M.D. Ph.D., Gretchen Y. Lopez-Hernandez, Ph.D., David A. Talmage, Ph.D., Lorna W. Role, Ph.D. Ch. 8: Autonomic Nervous System Transmission Peter B. Sargent, Ph.D. Ch. 9: Nicotinic Receptors in the Spinal Cord Boris Lamotte d’Incamps, Philippe Ascher Ch. 10: Slow Synaptic Transmission in the Central Nervous System A. Rory McQuiston, Ph.D Ch. 11: The Effects of Nicotine on Learning and Memory Thomas J. Gould, Ph.D Ch. 12: Nicotinic Receptors as Targets for Novel Analgesics and Anti-Inflammatory Drugs M. Imad Damaj, Ph.D., Kelen Freitas, Deniz Bagdas, Ph.D., Pamela Flood, M.D. Ch. 13: Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit Michael Paolini, M.D., Mariella De Biasi, Ph.D., John A. Dani, Ph.D. Ch. 14: Role of Central Serotonin Receptors in Nicotine Addiction Giuseppe Di Giovanni , Ph.D., Massimo Pierucci, B.Sc. Stephanie Chambers, Lucy Partridge, Philippe De Deurwaerdre, Ph.D., Ch. 15: Neuronal Nicotinic Acetylcholine Receptors in Reward and Addiction Andrew R. Tapper, Ph.D., Linzy M. Hendrickson, Ph.D. Ch. 16: Genetic Contributions of the a5 Nicotinic Receptor Subunit to Smoking Behavior Laura J. Bierut, M.D., Jerry A. Stitzel, Ph.D. Ch. 17: Smoking-Related Genes and Functional Consequences Ines Ibaez-Tallon, Ph.D., Jessica L. Ables, M.D., Ph.D. Ch. 18: Nicotinic Acetylcholine Receptors Along the Habenulo-Interpeduncular Pathway: Roles in Nicotine Withdrawal and Other Aversive Aspects Dang Q. Dao, B.S., Ramiro Salas, Ph.D., Mariella De Biasi, Ph.D. Ch. 19: Nicotinic Acetylcholine Receptors in Alzheimer’s and Parkinson’s Disease Kelly T Dineley, Ph.D. Ch. 20: Nicotinic Receptors and Mental Illness Sherry Leonard, Ph.D. Ch. 21: Current & Future Trends in Drug Discovery and Development Related to Nicotinic Receptors Stephen P Arneric, Ph.D., Emanuele Sher, M.D., Ph.D.
