Description
This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington’s disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases. Series Preface… Preface… Table of Contents… Contributing Authors… Part I Introduction 1. Prevalence, Needs, Strategies, and Risk Factors for Neurodegenerative Diseases Philip V. Peplow, Bridget Martinez, and Thomas A. Gennarelli Part II Research Methods 2. Activation of Microglia and Macrophages in Neurodegenerative Diseases Anna Salamero-Boix, Michael Schulz, and Lisa Sevenich 3. Activation of Astrocytes in Neurodegenerative Diseases Jiatong Li and Song Qin 4. Tau Pathology in Neurodegenerative Diseases Thomas Vogels and TomS Hromdka 5. Role of SIRT3 and Mitochondrial Dysfunction in Neurodegeneration Jin-Hui Hor, Munirah Mohamad Santosa, and Shi-Yan Ng 6. Oxidative Stress and Cellular Dysfunction in Neurodegeneratiove Disease Anju Singh, Ritushree Kukreti, and Shrikant Kukreti 7. Biomarkers in Parkinson’s Disease Andrei Surguchov 8. Metabolomic Biomarkers in Parkinson’s Disease Yaping Shao, Xiaojiao Xu, Nanxing Wang, Guowang Xu, and Weidong Le 9. Neuroinflammation in Huntington’s Disease John D. Lee, Martin W. Lo, Jenny N.T. Fung, and Trent M. Woodruff 10. Biomarkers in Huntington Disease Annie Killoran 11. Biofluid Biomarkers of Amyotrophic Lateral Sclerosis Cory J. Holdom, Frederik J. Steyn, Robert D. Henderson, Pamela A. McCombe, Mary-Louise Rogers, and Shyuan T. Ngo 12. MicroRNAs in Blood Serum, Blood Plasma, and Cerebrospinal Fluid as Diagnostic Biomarkers of Alzheimer’s Disease Philip V. Peplow and Bridget Martinez 13. Tau Biomarkers for Long-Term Effects of Neurotrauma: Technology Versus the Null Hypothesis Rudolph J. Castellani 14. Impedimetric Immunosensing for Neuroinflammatory Biomarker Profiling Andrea Cruz, Catarina M. Abreu, Paulo P. Freitas, and Ins Mendes Pinto 15. Aptamers Detection of Neurodegenerative Disease Biomarkers Hui Xi and Yang Zhang 16. Possible Biomarkers for Frontotemporal Dementia and to Differentiate from Alzheimer’s Disease and Amyotrophic Lateral Sclerosis Donald M.R. Harker, Bridget Martinez, and Ruben K. Dagda Part III Clinical Methods 17. TSPO PET Imaging as a Biomarker of Neuroinflammation in Neurodegenerative Disorders Eryn L. Werry, Fiona M. Bright, and Michael Kassiou 18. Validation of Diffusion Kurtosis Imaging as an Early Stage Biomarker of Parkinson’s Disease in Animal Models Amit Kharinar, Eva Drazanova, Nikoletta Szabo, and Jana Ruda-Kucerova 19. Imaging Biomarkers in Huntington’s Disease Edoardo Rosario de Natale, Heather Wilson, and Marios Politis 20. Imaging Biomarkers in Amyotrophic Lateral Sclerosis Leonor Cerd Alberich, Juan Francisco Vzquez Costa, Amadeo Ten-Esteve, Miguel Mazn, and Luis Marti-Bonmati Part IV Conclusion 21. Trends in Biomarkers of Neurodegenerative Diseases Philip V. Peplow, Bridget Martinez, and Thomas A. Gennarelli Addendum… Subject Index List…
