Description
In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Introduction and Overview Transgenic and Knockout Models of Psychiatric Disorders: Introduction, History, and Assessment Gene S. Fisch Transgenic Mouse Models and Human Psychiatric Disease Jonathan Flint Transgenic and Knockout Mouse Models: The Problem of Language Linda J. Hayes and Diana Delgado If Only They Could Talk: Genetic Mouse Models for Psychiatric Disorders Trevor Humby and Lawrence Wilkinson Transgenic and Knockout Models of Neurocognitive Dysfunction Spinocerebellar Ataxia Type 1: Lessons From Modeling a Movement Disease in Mice Harry T. Orr Mouse Models of Hereditary Mental Retardation Hans Welzl, Patrizia D’Adamo, David P. Wolfer, and Hans-Peter Lipp How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders? Simon E. Fisher Animal Models of Autism: Proposed Behavioral Paradigms and Biological Studies Thomas Bourgeron, Stphane Jamain, and Sylvie Granon Transgenic and Knockout Models of Neuropsychiatric Dysfunction Genetic Mouse Models of Psychiatric Disorders: Advantages, Limitations, and Challenges Joseph A. Gogos and Maria Karayiorgou Animal Models of Psychosis Stephen I. Deutsch, Katrice Long, Richard B. Rosse, Yousef Tizabi, Ronit Weizman, Judy Eller, and John Mastropaolo Animal Models of Anxiety: The Ethological Perspective Robert Gerlai, Robert Blanchard, and Caroline Blanchard Modeling Human Anxiety and Depression in Mutant Mice Andrew Holmes and John F. Cryan Mutant Mouse Models of Bipolar Disorder: Are There Any? Anneloes Dirks, Lucianne Groenink, and Berend Olivier Index
