Description
In spite of their relatively low prevalence, systemic vasculitides have been the object of intensive basic and clinical investigations over the last few years. As a consequence, important advancements have been achieved: from updated diagnostic and classification criteria and a more rational nomenclature to the recognition of an expanding spectrum of clinical manifestations and potentially devastating complications; from the recognition of the viral etiology of conditions such as HCV-related cryoglobulinemic vasculitis and HBV-associated polyarteritis nodosa to newly named variable vessel vasculitis exemplified by Behet’s disease; from single-organ vasculitis such as central nervous system vasculitis to the more recently emerging features of the IgG4-related, immune-mediated diseases that are showing remarkable clinical heterogeneity. In addition, intriguing pathogenetic hypotheses are being reported for certain chronic, relapsing vasculitides that are improving our understanding of their biology and basic pathophysiology. New avenues are being explored that will hopefully allow a deeper comprehension of the relationships between certain virus-driven vasculitides and lymphoproliferation, and possibly lead to the identification of novel biomarkers that may be used to single out patients at an increased risk of relapse. This explosion of knowledge is obviously resulting in state-of-the-art, personalized treatments of systemic vasculitides. This book is a collection of reviews on the major vasculitides, written by scientists and clinicians with a multi-year experience in this field. We hope it will provide the reader with a stimulating container of new advances in scientific knowledge and more rational therapeutic approaches to this fascinating chapter of pathology. Franco Dammacco is Emeritus Professor of Internal Medicine at the University of Bari Medical School and has been President of the Italian Society of Internal Medicine. His research and clinical interests include HCV-related cryoglobulinemic vasculitis, onco-hematology, connective tissue diseases and immunodeficiency syndromes. He is author or co-author of more than 470 papers and Editor-in-Chief of the journal Clinical and Experimental Medicine. Domenico Ribatti is full Professor of Human Anatomy at the University of Bari Medical School. His main research topics are angiogenesis and anti-angiogenesis, with special emphasis for hematological malignancies, tumor microcirculation, and immunological competence. He is author of over 650 papers and 8 monographs. Angelo Vacca is full Professor of Internal Medicine at the University of Bari Medical School and President of the Italian Society of Immunology, Clinical Immunology and Allergology. He is actively involved in research areas such as angiogenesis and tumor progression, multiple myeloma and related malignancies, biological markers of tumor invasion and metastasis, and controlled chemotherapy studies. On these topics he has published over 300 papers. SYSTEMIC VASCULITIDES: CURRENT STATUS AND PERSPECTIVES Editors: Franco Dammacco, Domenico Ribatti, Angelo Vacca Table of Contents I. Biology of Blood Vessels, Experimental Models and Nomenclature of Vasculitides Chapter 1 Morphofunctional Aspects of Endothelium Domenico Ribatti (Bari, Italy) Chapter 2 Animal Models of ANCA-Associated Vasculitis Domenico Ribatti, Franco Dammacco (Bari, Italy) Chapter 3 Nomenclature of Vasculitides: 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides and Beyond J. Charles Jennette, Ronald J. Falk, Marco A. Alba (Chapel Hill, NC, USA) Chapter 4 Search for Autoantibodies in Systemic Vasculitis: is it Useful? Joice Belem, Bruna Saviol, Alexandre Wagner Silva de Souza (So Paul, Brasil)Chapter 5Pathogenic Role of ANCA in Small Vessel Inflammation and Neutrophil Function Giuseppe A. Ramirez, Angelo A. Manfredi (Milan, Italy) II. Primary Systemic VasculitidesChapter 6 Takayasu Arteritis: When Rarity Maintains the Mystery Enrico Tombetti, Elena Baldissera, Angelo A. Manfredi, Maria Grazia Sabbadini (Milan, Italy) Chapter 7 Takayasu Arteritis and Ulcerative Colitis: A Frequent Association? Chikashi Terao (Boston, MA, USA) Chapter 8 Giant Cell Arteritis Silvia Laura Bosello, Elisa Gremese, Angela Carbonella, Federico Parisi, Francesco Cianci, Gianfranco Ferraccioli (Rome, Italy) Chapter 9 HLA System and Giant Cell Arteritis F. David Carmona, Javier Martn (Granada, Spain) Chapter 10 Microscopic Polyangiitis Franco Dammacco, Angelo Vacca (Bari, Italy) Chapter 11 Granulomatosis with Polyangiitis (Wegener’s) Franco Dammacco, Sebastiano Cicco, Domenico Ribatti, Angelo Vacca (Bari, Italy) Chapter 12 Eosinophilic Granulomatosis with Polyangiitis (Churg Strauss Syndrome) Renato Alberto Sinico, Paolo Bottero (Milan, Italy) Chapter 13 ANCA-Associated Vasculitis and the Mechanisms of Tissue Injury Adrian Schreiber, Mira Choi (Berlin, Germany) Chapter 14 Long-Term Outcome of ANCA-Associated Systemic Vasculitis James Ritchie, Timothy Reynolds, Joanna Robson (Bristol, U.K.) Chapter 15 Kawasaki Disease: Past, Present and Future Fernanda Falcini, Gemma Lepri (Florence, Italy) Chapter 16 Polyarteritis Nodosa Nicol Pipitone, Carlo Salvarani (Reggio Emilia, Italy) Chapter 17 Anti-Glomerular Basement Membrane Disease Michele Rossini, Annamaria Di Palma, Vito Racanelli, Franco Dammacco, Loreto Gesualdo (Bari, Italy) Chapter 18 IgA Vasculitis Roberta Fenoglio, Dario Roccatello (Turin, Italy) Chapter 19 Systemic Vasculitis and Pregnancy Maria Grazia Lazzaroni, Micaela Fredi, Sonia Zatti, Andrea Lojacono, Angela Tincani (Brescia, Italy) Chapter 20 Behet Disease Rosaria Talarico, Stefano Bombardieri (Pisa, Italy) Chapter 21 Small Vessel Vasculitis of the Skin Robert G. Micheletti (Philadelphia, PA, USA) Chapter 22 Adult Primary Central Nervous System Vasculitis Carlo Salvarani, Robert D. Brown, Jr, Caterina Giannini, Gene G. Hunder (Reggio Emilia, Italy; Rochester, MN, USA) Chapter 23 Diagnosis and Therapy of Peripheral Vasculitic Neuropathy Franz Blaes (Gummersbach, Germany) Chapter 24 Childhood Uveitis Alice Brambilla, Rolando Cimaz, Gabriele Simonini (Florence, Italy) Chapter 25 Cogan’s Syndrome Rosanna Dammacco (Bari, Italy) Chapter 26 Non-Infectious Retinal Vasculitis Shiri Shulman, Zohar Habot- Wilner (Tel Aviv, Israel) Chapter 27 IgG4-Related Disease Emanuel Della Torre (Milan, Italy)Chapter 28 Urticarial Vasculitis. A Review of the Literature Giulia De Feo, Roberta Parente, Chiara Cardamone, Massimo Triggiani (Salerno, Italy) III. Secondary Vasculitides Chapter 29 HCV-Related Cryoglobulinemic Vasculitis: an Overview Franco Dammacco, Sabino Russi, Domenico Sansonno (Bari, Italy) Chapter 30 Vasculitis In Connective Tissue Diseases Patrizia Leone, Sebastiano Cicco, Angelo Vacca, Franco Dammacco, Vito Racanelli (Bari, Italy)Chapter 31 Buerger’s disease (Thromboangiitis Obliterans) Masayuki Sugimoto, Kimihio Komori (Nagoya, Japan)Chapter 32 Cannabis-Associated Vasculitis Anne Claire Desbois, Patrice Cacoub (Paris, France)IV. Diagnostic and Therapeutic Advances of Systemic Vasculitides Chapter 33 Imaging in systemic vasculitis Mazen Abusamaan, Patrick Norton, Klaus Hagspiel, Aditya Sharma (Charlottesville, VA, USA)Chapter 34 Therapeutic use of biologic agents in systemic vasculitides John Anthonypillai, Julian L. Ambrus Jr. (Buffalo, NY, USA)Chapter 35 Treatment of ANCA-Associated Vasculitides Loc Guillevin (Paris, France)
