Description
Preface: History of VGCCs STRUCTURAL AND MOLECULAR ASPECTS OF VGCCS 1. Measuring and manipulating calcium 2. Structure, function and subunit assembly of VGCC 3. Splice variation and RNA editing of VGCCs 4. Mechanisms of calcium channel permeation 5. Regulation by beta subunits 6. Regulation by alpha2 delta subunits 7. VGCCs in invertebrates REGULATION OF VGCCS 8. Modulation by GPCRs and second messengers 9. Trafficking of VGCCs 10. Calcium regulation 11. Calcium channel complexes with other channels 12. Regulation of gene transcription by VGCCs (PATHO)PHYSIOLOGY OF VGCCS 13. Lessons from knock-out and knock-in mice 14. VGCCs and synaptic transmission 15. Cardiovascular syste 16. Calcium channels and exocytosis in chromaffin cells 17. Calcium channels in the pancreas in health and disease 18. Skeletal muscle system 19. Auditory and visual systems 20. Calcium channels and pain transmission 21. Migraine 22. Epilepsy 23. Psychiatric disorders 24. Parkinson’s disease 25. Reproductive system 26. Cancer PHARMACOLOGY OF VGCCS 27. Molecular determinants of VGCC pharmacology 28. Interactions with peptide toxins 29. Clinical pharmacology and drug discovery
