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Trials for Cerebellar Ataxias: From Cellular Models to Human Therapies (Contemporary Clinical Neuroscience)

SKU: 9783031243448

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Trials for Cerebellar Ataxias: From Cellular Models to Human Therapies (Contemporary Clinical Neuroscience), Boris Kryzhanovsky, 9783031243448

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Part I: Basic Science of Cerebellum and Ataxias 1 Functional anatomy of the cerebellum 2 Cerebellar physiology 3 Cerebellar biochemistry/pharmacology 4 Genetics of dominant ataxias 5 Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics 6 Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches 7 Ion Channel Genes and Ataxia Part II: Biomarkers and tools of trials 8 How to Design a Therapeutic Trial in SCAs 9 Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers 10 Clinical rating scales for ataxia 11 Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding 12 Cerebellar learning in the prism adaptation task 13 Blood and CSF biomarkers in autosomal dominant cerebellar ataxias Part III: Autosomal Dominant Cerebellar Ataxias 14 Riluzole in progressive cerebellar ataxias 15 ASOs against ATXN2 in preclinical and phase 1 trials 16 Antisense oligonucleotide therapy against SCA3 17 Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities 18 Experimental neurotransplantation for cerebellar ataxias 19 Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside 20 Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia 21 Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias 22 Physical therapy in Cerebellar Ataxia Part IV: Autosomal Recessive Cerebellar Ataxias 23 Recent advances on therapeutic approaches for Friedreich’s Ataxia 24 Therapeutic use of interferon gamma in Friedreich ataxia 25 Metabolic treatments of cerebellar ataxia 26 Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome Part V: Sporadic Ataxias 27 Therapeutic strategies in immune-mediated cerebellar ataxias 28 Coenzyme Q10 in MSA 29 State of the Art and History of Therapeutics in Ataxias

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