Description
1. Learning to think critically 2. Making the right decision 3. The drug discovery and development process (general) How are modern technologies developed and applied to drug discovery and development? 4. Human genome 5. High throughput screening 6. Structure-based drug design 7. Modern chemical synthesis 8. Antibody therapy 9. Discovery toxicology 10. Modern drug metabolism and pharmacokinetics 11. Modern pharmaceutics 12. Translational medicine 13. Biotechnology in general Drug discovery and development case study 14. Atorvastatin (how the 3rd statin became the best in class) 15. Apixaban (how distribution selectivity led to the discovery of apixaban) 16. Saxagliptin (how to solve animal specific toxicity issues) 17. Sustiva (how to solve animal specific toxicity issues) 18. Empagliflozin (drug degradation issue for carcinogenicity) 19. Tolfacitinib (Jak kinase inhibitor) 20. Dasatinib (discovery example for new indications) 21. Crizotinib (translational medicine example for a new indication) 22. Ipilimumab (CTLA4, 1st immune-oncology) 23. Nivolumab or pembrolizumab (PD-1) 24. Artemisinin (creative thinking to discover Artemisinin, Nobel Prize winning case) 25. Imatinib (1st TKI) 26. Deutetrabenazine (1st deuterium drug) 27. Esmolol (soft drug design) 28. Troglitazone (withdrawn from the market) 29. Solanezumab (failed in phase III) 30. Fasiglifam (failed in phase III) Conclusion 31. How to apply lessons learned from the case studies in drug discovery and development
