Description
This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory. Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research. 1. Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides Fabienne Danhier, Pierre Danhier, Nathalie Schleich, Chrystelle Po, S. Laurentc, P. Sibret, C. Jrme, V. Poucelle, Bernard Gallez, and Vronique Prat 2. Fabrication of cRGD Conjugated Dual Responsive Micelles to Target av5 Integrin Overexpressed Cancer Huacheng He, Remant Bahadur K.C., and Peisheng Xu 3. Copper-Free Click Chemistry Modification of Nanovectors for Integrin Targeted Cancer Therapy Chang-Fang Wang and Hlder A. Santos 4. Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal D oxorubicin Modified with Different cRGD Peptides Mohamadreza Amin and Mahmoud Reza Jaafari 5. Preparation of Heterobivalent and Multivalent Radiopharmarmaceuticals to Target Tumors Over-Expressing Integrins Guillermina Ferro-Flores, Blanca Ocampo-Garca, Clara Santos-Cuevas, Nallely Jimnez-Mancilla, Myrna Luna-Gutirrez, Flor de M. Ramrez, Enrique Morales-Avila, Luis M. De Len-Rodrguez, and Erika Azorn-Vega 6. 177Lu Labeled RGD-BBN Peptide for Targeting Prostate Cancer Lei Jiang and Zhen Cheng 7. Integrin-Mediated Targeting of Liposomally-Bound siRNAs to Tumor Vasculatures Poulami Ma jumder and Arabinda Chaudhuri 8. Integrin av3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide Hao Hong and Weibo Cai 9. Integrin Targeting Using RGD-Based Peptide Amphiphiles Poonam Saraf, Xiaoling Li, and Bhaskara Jasti 10. Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, T. Srinivasa Reddy, Ayan Kumar Barui, Chitta Ranjan Patra, Naidu V.G.M., David J. Adams, and Ramakrishna Sistla 11. Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds Via Integrin Receptors &n bsp; Jitka Neburkova, Miroslav Hajek, Ivan Rehor, Jiri Schimer, Frantisek Sedlak, Jan Stursa, Martin Hruby, and Petr Cigler 12. NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating IR-780 Ye Kuang, Kunchi Zhang, Min Liu, and Renjun Pei 13. Synergistic Active Targeting to B16F10 Tumors by av3/CD44-Targeted Nanoparticles Loaded with Docetaxel Sanjun Shi
