Description
This practical volume examines a number of topics that explore the current status of immunotherapy and diagnostic markers for neurodegenerative disorders. With a focus on Alzheimer’s disease, the first sections of the book examine immunotherapeutic approaches for the aforementioned disease as well as for Parkinson’s disease and Huntington’s disease, amongst others. The last section of the book covers the importance of biomarker techniques to catch these diseases early enough for the treatments to be most useful. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of detailed descriptions and implementation advice that will offer a smooth transition into the lab. Authoritative and useful, Immunotherapy and Biomarkers in Neurodegenerative Disorders aims to aid in the continued progress in the development of novel immune-based drugs and diagnostic tools for these devastating brain diseases. Part I: Immunotherapy Against Amyloid- b in Alzheimer’s Disease 1. Immunotherapy Against Amyloid- in Alzheimer’s Disease: An Overview Niels D. Prins 2. Active Immunization Against the Amyloid- Peptide Enchi Liu and J. Michael Ryan 3. Immunotherapy Against N-Truncated Amyloid- Oligomers Thomas A. Bayer and Oliver Wirths 4. Immunotherapy Against Amyloid- Protofibrils: Opportunities and Challenges Lars Lannfelt Part II: Immunotherapy in Other Neurodegenerative Disorders 5. Immunotherapy Against a-Synuclein Pathology Elvira Valera and Eliezer Masliah 6. Extracellular a-Synuclein as a Target for Immunotherapy Jun Sung Lee and Seung-Jae Lee 7. Immunotherapy of Parkinson’s Disease Achim Schneeberger, Suzanne Hendrix, and Markus Mandler 8. Tau Immunotherapy Einar M. Sigurdsson 9. Active and Passive Immunotherapy Against Tau: Effects and Potential Mechanisms Kiran Yanamandra, Marc I. Diamond, and David M. Holtzman 10. Immunotherapy on Experimental Models for Huntington’s Disease Anne Messer Part III: Biomarkers for Neurodegenerative Disorders 11. Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease Henrik Zetterberg and Jonathan M. Schott 12. Volumetric MRI as a Diagnostic Tool in Alzheimer’s Disease Eric Westman, Lena Cavalin, and Lars-Olof Wahlund 13. PET Imaging as a Diagnostic Tool in Alzheimers Disease Juha O. Rinne 14. lpha-Synuclein as a Diagnostic Biomarker for Parkinson’s Disease Joakim Bergstrm and Martin Ingelsson 15. Imaging as a Diagnostic Tool in Parkinson’s Disease Johan Wikstrm and Torsten Danfors 16. Mass S pectrometry-B ased P roteomics in B iomarker D iscovery for N eurodegenerative D iseases Sravani Musunuri, Ganna Shevchenko, and Jonas Bergquist
