Description
Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine. Part I Virology, Pathogenesis, and Clinical and Epidemiological Features of Disease Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease Peter L. Collins, Rachel Fearns, and Barney S. Graham Clinical and Epidemiologic Features of Respiratory Syncytial Virus Caroline B. Hall, Eric A. F. Simoes, and Larry J. Anderson Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity Jos A. Melero and Martin L. Moore Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins Jason S. McLellan, William C. Ray and Mark E. Peeples Respiratory Syncytial Virus and Reactive Airway Disease Matthew T. Lotz, Martin L. Moore, and R. Stokes Peebles, Jr. Part II Host Response to Infection and Genetics of Disease Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches Eun Hwa Choi, Hoan Jong Lee, and Stephen J. Chanock Innate Immune Responses to Respiratory Syncytial Virus Infection Sumanta Mukherjee and Nicholas W. Lukacs The Adaptive Immune Response to Respiratory Syncytial Virus Steven. M. Varga and Thomas J. Braciale Respiratory Syncytial Virus Mechanisms to Interfere with Type 1 Interferons Sailen Barik Host Gene Expression and Respiratory Syncytial Virus Infection Ralph A. Tripp, Asuncion Mejias, and Octavio Ramilo Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus Allison M.W. Malloy, Ann R. Falsey, and Tracy J. Ruckwardt Part III Vaccine Platforms and Treatment Options Respiratory Syncytial Virus Disease: Prevention and Treatment Helen Y. Chu and Janet A. Englund Live-Attenuated Respiratory Syncytial Virus Vaccines Ruth A. Karron, Ursula J. Buchholz, and Peter L. Collins Subunit and Virus-Like Particle Vaccine Approaches for Respiratory Syncytial Virus Trudy G. Morrison and Edward E. Walsh Gene-Based Vaccine Approaches for Respiratory Syncytial Virus Rebecca J. Loomis and Philip R. Johnson Part IV Animal and Tissue Culture Models of Infection Bovine Model of Respiratory Syncytial Virus Infection Geraldine Taylor The Cotton Rat S. hispidus Model of Respiratory Syncytial Virus Infection Marina S. Boukhvalova and Jorge C.G. Blanco The Mouse Model of Respiratory Syncytial Virus Disease Peter J. Openshaw Human Airway Epithelial Cell Cultures for Modeling Respiratory Syncytial Virus Infection Raymond J. Pickles Part V Conclusions Challenges and Opportunities for Respiratory Syncytial Virus Vaccines Barney S. Graham and Larry J. Anderson
