Description
This book presents the development and experimental validation of the structural test strategy called Oscillation-Based Test – OBT in short. The results presented here assert, not only from a theoretical point of view, but also based on a wide experimental support, that OBT is an efficient defect-oriented test solution, complementing the existing functional test techniques for mixed-signal circuits. Peripheral and Central Mechanisms of Pain Generation.- Drugs in Clinical Use.- Opioids.- Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones.- Local Anesthetics.- Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headache.- Anti-convulsants and Anti-depressants.- Compounds in Preclinical Development.- Neuropeptide and Kinin Antagonists.- Glutamate Receptor Ligands.- Adrenergic and Cholinergic Compounds.- Cannabinoids and Pain.- Future Targets in Analgesia Research.- Adenosine and ATP Receptors.- Ion Channels in Analgesia Research.- Protein Kinases as Potential Targets for the Treatment of Pathological Pain.- Pain Management Beyond Pharmacotherapy.- Placebo and Endogenous Mechanisms of Analgesia.- Limitations of Pharmacotherapy: Behavioral Approaches to Chronic Pain.
