Description
The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 1 examines general assessments in morphology, physiology, biochemistry and molecular biology, neurobehavior, and neuroimaging, as well as extensive sections on subarachnoid hemorrhage, cerebral vasospasm, and intracerebral hemorrhage. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments. Part I: General Morphological Assessments 1. Histopathological Assessments of Animal Models of Cerebral Ischemia Ami P. Raval and Bingren Hu 2. Assessment of Cell Death: Apoptosis, Necrosis, or In Between Tom Genetta, Ling Wei, and Shan Ping Yu 3. The Stereology and 3D Volume Analyses in Nervous Tissue Rabindra P. Singh, Li Shen, and Feng C. Zhou 4. Assessments of Reactive Astrogliosis Following CNS Injuries Candace L. Floyd Part II: General Physiological Assessments 5. Physiological Assessment in Stroke Research Casey Lee Hall, Osama Mohamad, Shan Ping Yu, and Ling Wei 6. EEG, Evoked Potential (EP), and Extracellular Single Unit Recordings In Vivo Jie Wu 7. Intracellular Recording In Vivo and Patch-Clamp Recording on Brain Slices Ping Deng and Zao C. Xu 8. Electrophysiological Evaluation of Synaptic Plasticity in Injured CNS Xiaoming Jin Part III: General Biochemical and Molecular Biological Assessments 9. Characterization of RNA Marcel P. Van der Brug, Mar Matarin, and Taura L. Barr 10. MicroRNA Expression Profiling of Rat Blood and Brain Tissues: TaqMan Real-Time PCR MicroRNA Assays Da-Zhi Liu, Bradley P. Ander, and Frank R. Sharp 11. Protein Analysis Anthony Kian-Fong Liou and Jun Chen 12. Application of Zymographic Methods to Study Matrix Enzymes Following Traumatic Brain Injury Lesley K. Harris, Raiford T. Black, Thomas M. Reeves, and Linda L. Phillips Part IV: General Neurobehavioral Assessments 13. Rodent Behavioral Assessment in the Home Cage Using the SmartCageTM System Xinmin Simon Xie, Jingxi Zhang , Bende Zou, James Xie, Jidong Fang, Nurulain T. Zaveri, and Taline V. Khroyan 14. Assessments of Cognitive Function Following Traumatic Brain Injury Wendy M. Reid and Dong Sun 15. Assessment of Cognitive and Sensorimotor Deficits Richard E. Hartman 16. Emotional and Anxiety Assessments in CNS Disorders Zaorui Zhao and Junfang Wu Part V: General Neuroimaging Assessments 17. Neuroimaging Assessment of Traumatic Brain Injury Janna L. Harris and William M. Brooks 18. Imaging of Myelin by Coherent Anti-Stokes Raman Scattering Microscopy Ji-Xin Cheng Part VI: Subarachnoid Hemorrhage 19. Grading Scales for Subarachnoid Hemorrhage Andrew Losiniecki and Mario Zuccarello 20. Acute Physiologic and Morphologic Assessment Following Subarachnoid Hemorrhage Vincent DiNapoli and Mario Zuccarello 21. Aneurysmal Subarachnoid Hemorrhage Grading in Animal Models Robert Ayer, Takashi Sugawara, and John H. Zhang 22. Physiological Assessments of Subarachnoid Hemorrhage Jens P. Dreier 23. Spreading Depolarization Clemens Reiffurth, Sergei A. Kirov, and Jens P. Dreier 24. Assessment of Neurovascular Coupling Cecilia Nicoletti, Nikolas Offenhauser, Devi Jorks, Sebastian Major, and Jens P. Dreier 25. Assessment of Global Ischemia Fatima A. Sehba and Joshua B. Bederson 26. Assessment of Microthromboembolism after Subarachnoid Hemorrhage Mervyn D.I. Vergouwen and R. Loch Macdonald 27. Intracranial Pressure Assessments Carla S. Jung and Andreas W. Unterberg 28. Assessment of Blood-Brain Barrier Breakdown Yoash Hassidim, Ofer Prager, Ilan Shelef, and Alon Friedman 29. Electrophysiology and Morris Water Maze to Assess Hippocampal Function after Experimental Subarachnoid Hemorrhage Asma Tariq and R. Loch Macdonald 30. Biochemical and Molecular Biological Assessments of Subarachnoid Hemorrhage Joseph F. Clark 31. Neurobehavioral Assessments of Subarachnoid Hemorrhage Hidenori Suzuki and John H. Zhang 32. Neuroimaging Assessment of Subarachnoid Hemorrhage Andre Obenaus and Sam Barnes Part VII: Cerebral Vasospasm 33. Introduction to Problems of Post-Subarachnoid Hemorrhage Delayed Cerebral Vasospasm Ryszard M. Pluta 34. Morphological Assessments of Cerebral Vasospasm Hiroki Ohkuma 35. Vasospasm: Measurement of Diameter, Perimeter and Wall Thickness Mohammed Sabri and R. Loch Macdonald 36. Light Microscopic Assessment Akira Munakata, Norihito Shimamura, and Hiroki Ohkuma 37. Electron Microscopic Assessment Norihito Shimamura, Akira Munakata, and Hiroki Ohkuma 38. Morphological Assessment of Microcirculation Hiroki Ohkuma and Shigeharu Suzuki 39. Electrophysiological Assessment of Cerebral Vasospasm Jinglu Ai and R. Loch Macdonald 40. Cranial Window Assessments in Experimental aSAH in Mice Ulf C. Schneider, Etienne N. Atangana, and Peter Vajkoczy 41. Laser Speckle Contrast Analysis (LASCA) Imaging Nils Hecht, Ulf Schneider, Johannes Woitzik, and Peter Vajkoczy 42. Ion Channel Assessment Marcel Alexander Kamp, Hans-Jakob Steiger, and Daniel Hnggi 43. Biochemical Assessments of Cerebral Vasospasm: Measurement of cGMP, PKC, and PTK in Cerebral Arteries Masayo Koide and Shigeru Nishizawa 44. Assessment of Intracellular Calcium in Cerebral Artery Myocytes Matthew A. Nystoriak, Masayo Koide, and George C. Wellman 45. Neurobehavioral Assessments of Cerebral Vasospasm Ryszard M. Pluta, Boris Skopets, and Jerald D. Kralik 46. Neuroimaging Assessment of Cerebral Vasospasm Kaisorn L. Chaichana, Gustavo Pradilla, and Rafael J. Tamargo Part VIII: Intracerebral Hemorrhage 47. Morphological Assessment of Intracerebral Hemorrhage Qing Xie, Guohua Xi, and Ya Hua 48. Immunological Response to Experimental Intracerebral Hemorrhage: Morphological Assessments Elena Titova and Andre Obenaus 49. Intracranial Pressure Assessment Yangdong He, Ya Hua, and Guohua Xi 50. Hemoglobin Measurements Yangdong He, Ya Hua, and Guohua Xi 51. Biochemical and Molecular Biological Assessments of Intracerebral Hemorrhage Jin-Yul Lee, Ya Hua, Richard F. Keep, and Guohua Xi 52. Neurobehavioral Assessments of Intracerebral Hemorrhage Tim Lekic and John H. Zhang 53. Corner Turning Test for Evaluation of Asymmetry after Intracerebral Hemorrhage in Rodents Tim Lekic, William Rolland, Anatol Manaenko, Nancy Fathali, and John H. Zhang 54. Forelimb Use Asymmetry Analysis of Vertical Exploratory Activity after Intracerebral Hemorrhage in Rats and Mice Tim Lekic, Anatol Manaenko, and William Rolland, and John H. Zhang 55. The Vibrissae-Elicited Forelimb Placing Test after Intracerebral Hemorrhage in Rodents Tim Lekic, William Rolland, Anatol Manaenko, Nancy Fathali, and John H. Zhang 56. Imaging of Hematoma and Perihematomal Edema in Experimental Intracerebral Hemorrhage Veit Rohde, Walter Schulz-Schffer, and Timo Krings
