Description
This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs. Part I: Novel Approaches for the Treatment of Epilepsy 1. Inflammatory Cytokines as Targets for Epilepsy Drug Therapy Mara-Leonor Lpez-Meraz, Jess-Servando Medel-Matus, and Jerome Niquet 2. The Use of Anti-Inflammatory Drugs in Epilepsy Mara Guadalupe Valle-Dorado, Laura Elena Crdova-Dvalos, Daniel Prez-Prez, Rosalinda Guevara-Guzmn, and Luisa Rocha 3. Carbonic Anhydrase and Epilepsy Luciana Gavernet 4. Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs Luz Adriana Pichardo-Macas, Itzel Jatziri Contreras-Garca, Sergio R. Zamudio, Edgar Mixcoha, and Julieta G. Mendoza-Torreblanca 5. Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy? Cecilia Zavala-Tecuapetla and Luisa Rocha 6. Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy Manola Cuellar-Herrera, Csar E. Santana-Gmez, Francia Carmona-Cruz, Daruni Vzquez-Barrn, Francisco Velasco, and Ana L. Velasco 7. Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity Suchitra Joshi and Jaideep Kapur 8. Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy Amalia Marelli, Liliana Czornyj, Luisa Rocha, and Alberto Lazarowski 9. Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery Karla G. Carvajal Aguilera and Bryan V. Phillips Farfn 10. Gene Therapy in Epilepsy Miguel A. Lpez-Garca, Iris A. Feria-Romero, Julia J. Segura-Uribe, David Escalante-Santiago, and Sandra Orozco-Suarez Part II: Innovative Solutions for the Screening of New Antiepileptics Drugs and Addressing the Multi-Drug Resistance Issue Epilepsy 11. Human Brain Tissue as a Model for the Study of Epilepsy Leonardo Lara-Valderrbano, Ivette Bauelos-Cabrera, Vctor Navarrete-Modesto, and Luisa Rocha 12. The Blood-Brain Barrier and the Design of New Antiepileptic Drugs Gabriela Rogel-Salazar and Hiram Luna-Munguia 13. Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates Alan Talevi and Luis E. Bruno-Blanch 14. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations Manuel Couyoupetrou, Mauricio Di Ianni, Melisa Gantner, Guido Pesce, Roxana Peroni, Alan Talevi, and Luis E. Bruno-Blanch 15. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations Pablo Palestro and Luciana Gavernet 16. Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies Mara E. Ruiz and Guillermo R. Castro Part III: Potential Contributions of Network Pharmacology and Drug Repurposing in Antiepileptic Drug Discovery 17. Side Effects of Antiepileptic Drugs Hana Kubova 18. Network Pharmacology and Epilepsy Alan Talevi 19. The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development Alan Talevi
