Description
Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology(TM) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery. 1. Cell Perturbation Screens for Target Identification by RNAi Kubilay Demir and Michael Boutros 2. Using Functional Genomics to Identify Drug Targets: a Dupuytren’s Disease Example Mirela Sedic, Sandra Kraljevic Pavelic, Karlo Hock 3. Functional Characterization of Human Genes from Exon Expression and RNA Interference Results Dorothea Emig, Hagen Blankenburg, Fidel Ramrez, and Mario Albrecht 4. Barcode Sequencing for Understanding Drug-gene Interactions Andrew M. Smith, Tanja Durbic, Saranya Kittanakom, Guri Giaever, Corey Nislow 5. High-Throughput Sequencing of the Methylome Using Two-Base Encoding Christina A. Bormann Chung 6. Applications and Limitations of In Silico Models In Drug Discovery Ahmet Secan, Sean Ekins, and Sandhya Kortagere 7. Compound Collection Preparation for Virtual Screening Cristian G. Bologa and Tudor I. Oprea 8. Mapping Between Databases of Compounds and Protein Targest Sorel Muresan, Markus Sitzmann, and Christopher Southan 9. Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro-Array and Gene Expression Data N. Sukumar, Michael P. Krein, Mark J. Embrechts 10. Advances in Nuclear Magnetic Resonance for Drug Discovery Laurel O. Sillerud, and Richard S. Larson 11. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance Toshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami 12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selection Javier De Las Rivas and Carlos Prieto 13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network Analysis Benjamin J. Keller, Sebastian Martini, Viji Nair 14. Models of Excitation-Contraction Coupling in Cardiac Ventricular Myocytes M. Saleet Jafri 15. Integration of Multiple Ubiquitin Signals in Proteasome Regulation Marta Isasa, Alice Zuin and Bernat Crosas 4. Barcode Sequencing for Understanding Drug-gene Interactions Andrew M. Smith, Tanja Durbic, Saranya Kittanakom, Guri Giaever, Corey Nislow 5. High-Throughput Sequencing of the Methylome Using Two-Base Encoding Christina A. Bormann Chung 6. Applications and Limitations of In Silico Models In Drug Discovery Ahmet Secan, Sean Ekins, and Sandhya Kortagere 7. Compound Collection Preparation for Virtual Screening Cristian G. Bologa and Tudor I. Oprea 8. Mapping Between Databases of Compounds and Protein Targest Sorel Muresan, Markus Sitzmann, and Christopher Southan 9. Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro-Array and Gene Expression Data N. Sukumar, Michael P. Krein, Mark J. Embrechts 10. Advances in Nuclear Magnetic Resonance for Drug Discovery Laurel O. Sillerud, and Richard S. Larson 11. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance Toshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami 12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selection Javier De Las Rivas and Carlos Prieto 13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network Analysis Benjamin J. Keller, Sebastian Martini, Viji Nair 14. Models of Excitation-Contraction Coupling in Cardiac Ventricular Myocytes M. Saleet Jafri 15. Integration of Multiple Ubiquitin Signals in Proteasome Regulation Marta Isasa, Alice Zuin and Bernat Crosas 10. Advances in Nuclear Magnetic Resonance for Drug Discovery Laurel O. Sillerud, and Richard S. Larson 11. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance Toshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami 12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selection Javier De Las Rivas and Carlos Prieto 13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network Analysis Benjamin J. Keller, Sebastian Martini, Viji Nair 14. Models of Excitation-Contraction Coupling in Cardiac Ventricular Myocytes M. Saleet Jafri 15. Integration of Multiple Ubiquitin Signals in Proteasome Regulation Marta Isasa, Alice Zuin and Bernat Crosas 12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selection Javier De Las Rivas and Carlos Prieto 13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network Analysis Benjamin J. Keller, Sebastian Martini, Viji Nair 14. Models of Excitation-Contraction Coupling in Cardiac Ventricular Myocytes M. Saleet Jafri 15. Integration of Multiple Ubiquitin Signals in Proteasome Regulation Marta Isasa, Alice Zuin and Bernat Crosas
