Description
A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs. Part I. Antimutagens Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane Thomas W. Kensler and Paul Talalay Chemoprevention by Isothiocyanates Stephen S. Hecht Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine Silvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D’Agostini, Maria Bagnasco, and Roumen Balansky Modifiers of Cytochrome(s) P450 John DiGiovanni and Heather E. Kleiner Part II. Antiinflammatories Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism Gary B. Gordon, Gary J. Kelloff, and Caroline C. Sigman Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention Raymond N. DuBois Lipoxygenases as Targets for Cancer Prevention Susan M. Fischer and Russell D. Klein Inducible Nitric Oxide Synthase as a Target for Chemoprevention Lorne J. Hofseth, Tomohiro Sawa, S. Perwez Hussain, and Curtis C. Harris Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil Timothy S. Wiedmann and Lee W. Wattenberg Chemoprevention of Cancer by Curcumin Bandaru S. Reddy and Chinthalapally V. Rao Prostacyclin and Lung Cancer Chemoprevention Robert L. Keith, York E. Miller, Paul A. Bunn Jr., Patrick Nana-Sinkam, Raphael A. Nemenoff, and Mark W. Geraci Part III. Nuclear Receptor Superfamily Nuclear Receptor Superfamily: Targets for Chemoprevention Julia A. Lawrence and Kapil Dhingra A. Antiandrogens Prostate Cancer Chemoprevention: 5a-Reductase Inhibitors Jennifer E. Drisko and Siu-Long Yao Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer Mark S. Chapman,William Y. Chang, Andrs Negro-Vilar, and Jeffrey N. Miner B. Antiestrogens Aromatase Inhibitors as Chemopreventives of Breast Cancer Mitchell Dowsett and Judy E. Garber Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators Carolyn L. Smith C. Natural Vitamin D and Synthetic Analogs Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs Kathryn Z. Guyton, Thomas W. Kensler, and Gary H. Posner D. Retinoids The Retinoids and Cancer Chemoprevention Sutisak Kitareewan, Ian Pitha-Rowe, Yan Ma, Sarah J. Freemantle, and Ethan Dmitrovsky E. Dehydroepiandrosterone and Structural Analogs Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs Arthur G. Schwartz and Laura L. Pashko Part IV. Signal Transduction Modulators ras Oncogene Inhibitors Nancy E. Kohl The Potential of EGFR-Targeted Agents in Cancer Prevention Steven D. Averbuch and Fadlo R. Khuri Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors Paul Workman Therapeutic Strategies Targeting Polyamines Debora L. Kramer and Eugene W. Gerner The Role of Phytoestrogens as Cancer Prevention Agents Stephen Barnes and Coral A. Lamartiniere Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids Pamela L. Crowell and Michael N. Gould Development of an Inhibitor of raf Kinase Frank McCormick Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention Alessandro Sgambato and I. Bernard Weinstein Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy Melissa K. Reeder, Rifat Pamakcu, I. Bernard Weinstein, Kirk Hoffman, and W. Joseph
