Description
Section I The Rationale and Economics of Drug Repositioning Chapter 1 Scientific and Commercial Value of Drug Repurposing David Cavalla Chapter 2 Repurposing for Alzheimers and Parkinsons Diseases: The Ideas, the Pipeline, the Successes, and the Disappointments Hermann Mucke Chapter 3 Contribution of Not-for-Profit Organizations to Drug Repurposing Bruce Bloom Section II Repositioning Approaches and Technologies: From Serendipity to Systematic and Rational Strategies Chapter 4 Systematic Drug Repositioning Spyros N. Deftereos, Aris Persidis, Andreas Persidis, Eftychia Lekka, Christos Andronis, and Vassilis Virvillis Chapter 5 Technical Tools for Computational Drug Repositioning Francesco Napolitano Chapter 6 RNAi Screening toward Therapeutic Drug Repurposing Nichole Orr-Burks, Byoung-Shik Shim, Olivia Perwitasari, and Ralph A. Tripp Chapter 7 Phenotypic Screening Christine M. Macolino-Kane, John R. Ciallella, Christopher A. Lipinski, and Andrew G. Reaume Section III Drug Repositioning for Nervous System Diseases Chapter 8 A Case Study: Chlorpromazine Francisco Lpez-Munoz, Cecilio lamo, and Silvia E. Garca-Ramos Chapter 9 Drug Repurposing for Central Nervous System Disorders: A Pillar of New Drug Discovery Mondher Toumi, Aleksandra Caban, Anna Kapniak, Szymon Jarosawski, and Cecile Rmuzat Chapter 10 Repurposing Opportunities for Parkinsons Disease Therapies Giulia Ambrosi, Silvia Cerri, and Fabio Blandini Chapter 11 Drug Candidates for Repositioning in Alzheimers Disease Maria P. del Castillo-Frias and Andrew J. Doig Chapter 12 Promising Candidates for Drug Repurposing in Huntingtons Disease Francesca Romana Fusco and Emanuela Paldino Chapter 13 Drug Repositioning Opportunities in Psychiatry Alexander W. Charney, Joseph R. Scarpa, Douglas M. Ruderfer, and Dennis S. Charney Chapter 14 Pharmacology of Amyotrophic Lateral Sclerosis: Old Strategies and New Perspectives Tiziana Petrozziello, Valentina Tedeschi, Alba Esposito, and Agnese Secondo Chapter 15 Repositioning Clinic-Ready Compounds for the Treatment of Spinal Muscular Atrophy Faraz Farooq Chapter 16 Rescuing Ischemic Brain Injury by Targeting the Immune Response through Repositioned Drugs Diana Amantea and Giacinto Bagetta
