Description
This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing “true” DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer. Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer. Lisa A. Newman, MD, MPH, FACS Professor of Surgery, Director, Breast Care Center, University of Michigan Health System, Comprehensive Cancer Center, Ann Arbor, MI, USA Jessica M. Bensenhaver, MD Assistant Professor of Surgery, University of Michigan Health System, Comprehensive Cancer Center, Ann Arbor, MI, USA 1. Epidemiology of Ductal Carcinoma In Situ Prathima Kanumuri and Anees Chagpar 2. Role of Screening Mammography in Early Detection/Outcome from Breast Cancer Renee W. Pinsky and Mark A. Helvie 3. Imaging DCIS: Digital/Film Screening Mammography, Tomosynthesis, MRI, Ultrasonography Annette Ingram Joe and Stephanie K. Patterson 4. Pathology of Ductal Carcinoma In Situ: Features and Diagnostic Challenges Julie M. Jorns and Celina G. Kleer 5. Molecular Markers in DCIS Chelsea Horwood and Theresa L. Schwartz 6. History of Ductal Carcinoma In Situ Management Based Upon Data from Prospective, Randomized Clinical Trials Lisa A. Newman and Jessica M. Bensenhaver 7. Extent and Role of Margin Control for DCIS Managed by Breast-Conserving Surgery Melissa Pilewskie and Monica Morrow 8. Ductal Carcinoma In Situ Treated With Breast Conserving Surgery Alone Jessica M. Bensenhaver 9. DCIS Managed with BCS: Whole-Breast XRT vs. Partial Breast XRT Chirag Shah and Frank A. Vicini 10. Anti-HER2/neu Therapy in DCIS Amelia Tower, Ruta D. Rao, Kalliopi P. Siziopikou, Melody A. Cobleigh and Thomas B. Julian 11. Role of Genetic Profiling and Recurrence Scores in Treatment Planning for DCIS Julie A. Margenthaler and Amy E. Cyr 12. DCIS and Sentinel Lymph Node Biopsy Alfred J. Colfry, 3rd, Alastair M. Thompson and Henry Mark Kuerer 13. Role of Postmastectomy Radiation for DCIS Corey W. Speers and Reshma Jagsi 14. Monitoring and Surveillance Following DCIS Treatment Jennifer Zakhireh and E. Shelley Hwang 15. DCIS and Hereditary Susceptibility for Breast Cancer Patrick Pilie, Kara Milliron and Sofia D. Merajver 16. Introduction, Evolution and Application of the Van Nuys Prognostic Index in DCIS Aeisha K. S. Rivers 17. Disparities in DCIS Detection and Outcomes Related to Race/Ethnicity Erin A. Strong, Azadeh Stark and Lisa A. Newman
