Description
Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions. 1 Introduction to endocrine disruptors and Puberty Evanthia Diamanti-Kandarakis Andrea C. Gore Part I: EDCs, endocrine systems, and puberty 2 In utero exposure to environmental chemicals – Lessons from maternal cigarette smoking and its effects on gonad development and puberty Rebecca McKinlay Peter O’Shaughnessey Richard M. Sharpe Paul A. Fowler 3 Reproductive Neuroendocrine Targets of Developmental Exposure to Endocrine Disruptors Sarah M. Dickerson Stephanie L. Cunningham Andrea C. Gore 4 Endocrine disruptors and puberty disorders from mice to men (and women) Alberto Mantovani 5 Thyroid hormone regulation of mammalian reproductive development and the potential impact of endocrine disrupting chemicals Kara Renee Thoemke Thomas William Bastian Grant Wesley Anderson Part II: Developmental exposure to endocrine disruptors and adverse reproductive outcomes 6 Developmental exposure to endocrine disruptors and ovarian function Evanthia Diamanti-Kandarakis Eleni Palioura Eleni A.Kandaraki 7 Developmental exposure to environmental endocrine disruptors and adverse effects on mammary gland development Suzanne Fenton Lydia M. Beck Aditi R. Borde Jennifer Rayner 8 Developmental exposure to endocrine disruptors and male urogenital tract malformations Mariana F. Fernandez Nicolas Olea, MD PhD 9 EDC exposures and the development of reproductive and non-reproductive behaviors Amy B. Wisniewski Craige C. Wrenn Ashwini Mallappa Part III. Developmental exposure to endocrine disruptors and metabolic disorders 10 Adipocytes as target cells for endocrine disruption Amanda Janesick Bruce Blumberg 11 Altered Glucose Homeostasis Resulting From Developmental Exposures To Endocrine Disruptors Alan Schneyer Melissa Brown 12 Developmental Exposure to Endocrine Disrupting Chemicals: Is there a Connection with Birth and Childhood Weights? Elizabeth E. Hatch Jessica W Nelson Rebecca Triosi Linda Titus Part IV. EDCs and Human Health 13 The Impact Of Endocrine Disruptors On Female Pubertal Timing Jean-Pierre Bourguignon Anne-Simone Parent 14 The influence of endocrine disruptors on Male Pubertal Timing Xiu-feng Wu Ningning Zhang Mary M. Lee 15 Secular Trends in Pubertal Timing: A Role for Environmental Chemical Exposure? Vincent F. Garry Peter Truran, PhD
