Description
This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections: Evolution and detection of endogenous ADP-ribosylation ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs) ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs) The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives. Friedrich Koch-Nolte is a professor at University Hospital Hamburg-Eppendorf, Institute for Immunology, Hamburg, Germany Part I: Evolution and Detection of Endogenous ADP-Ribosylation The natural history of ADP-ribosyltransferases and the ADP ribosylation system L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer Identification and Analysis of ADP-ribosylated Proteins Friedrich Haag and Friedrich Buck Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs) Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine Klaus Aktories, Gudula Schmidt and Alexander E. Lang Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein Hideaki Tsuge, Toshiharu Tsurumura Regulation of nitrogenase by reversible mono-ADP-ribosylation Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells Bjrn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs) Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family Ana Filipa Pinto and Herwig Schler Function and regulation of the mono-ADP-ribosyltransferase ARTD10 Max Kaufmann, Karla L. H. Feijs, and Bernhard Lscher Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-1 mono-ADP-ribosylation by ARTD15 Maria Di Girolamo
