Description
This comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice. Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers. Corey Scher MD Clinical Professor of Anesthesiology New York University School of Medicine Bellevue Hospital Center New York, NY Alan David Kaye MD, PhD Vice-Chancellor of Academic Affairs, Chief Officer, and Provost Tenured Professor, Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences LSU School of Medicine Shreveport, LA USA Henry Liu MD Professor of Anesthesiology & Perioperative Medicine Milton S. Hershey Medical Center Penn State University College of Medicine Hershey, PA USA Seth Perleman MD Associate Professor of Anesthesiology New York University School of Medicine Langone Medical Center New York University School of Medicine New York, NY USA Sarah Leavitt MD Assistant Professor Department of Anesthesiology NYU Langone Medical Center Bellevue Hospital New York, NY USA The History of Blood Transfusions Modern Blood Banking Component Therapy and Whole Blood: Packed Red Blood Cells, Fresh Frozen Plasma, Cryoprecipitate, washed and or radiated red cells The Coagulation System and Clot Stability Fibrinolysis- Tranexamic Acid and Aminocaproic Acid. Hypercoagulation and Thrombotic Disorders: TTP, Factor 5 Leiden, Phospholipid Syndrome, Anti-thrombin 3, hypereosinophils, oxidative stress, cancer. Diseases or Conditions of Platelet Dysfunction The Massive Transfusion Protocol New Biologicals to Assist Clotting- Riastap, Prothrombin Concentrates. Antithrombin3, Fibrogammin and factor13, Fibrosupernatant, Fibrinogen Concentrates, Recombinant Factor 7, DDAVP, Octaplast G., Factor 10A, KCentra Biologicals that Inhibit Clot generation -The Heparins, Factor 10A inhibitors, rivaroxaban, apixaban, dabigatran, Point of Care Testing and Goal Directed Therapy- Thromboelastography, ROTEM, Platelet function analyzer, stat-PT, thrombin generation assays, multi-electro-aggregometry, OHP (Overall hemostatic potential assay), ACT. Complications of Blood Transfusions: TRALI, TACO, Blood type mismatch, infection Diseases of the Coagulation System- Hemophilia, VonWillebrand Disease, Cryoglobulinemia, Inborn Errors of Factor Synthesis Blood Conservation Strategies and Bloodless Surgery- normovolemic hemodilution, cell saver, Bridges to Transfusion when blood is not immediately available. Artificial Blood Preoperative correction of anemia Blood Deployment in Natural Disasters and the Military in Combat Commonly prescribed medications that affect clotting-anti-depressants, NSAIDS, ASA Anesthesia for the severe trauma patient- new evidence from new trials Old blood vs. new blood- Is storage injury a concern? Vascular Endothelial dysfunction and inflammatory states Liberal or restrictive blood transfusions
