Description
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis. Preface Roy G. Smith Chapter 1. Ghrelin: A History of Its Discovery Cyril Y. Bowers G.A. Reynolds Johannes D. Veldhuis Chapter 2. Enzymatic Processing of Ghrelin Precursor Masayasu Kojima Kenji Kangawa Chapter 3. Ghrelin’s Novel Signaling in Islet b-Cells to Inhibit Insulin Secretion and Its Blockade As a Promising Strategy to Treat Type 2 Diabetes Katsuya Dezaki Damdindorj Boldbaatar Tomoyuki Kurashina Toshihiko Yada Chapter 4. Gastric Ghrelin in the Regulation of Appetite and Metabolism Luisa Mara Seoane Ana Belen Crujeiras Omar Al-Massadi Felipe F. Casanueva Chapter 5. Ghrelin Regulation of AMPK in the Hypothalamus and Peripheral Tissues Miski Scerif Blerina Kola Mrta Korbonits Chapter 6. Ghrelin: Neuropeptide Regulator of Metabolism Pablo J. Enriori Zane Andrews Michael Alexander Cowley Chapter 7. GOAT and the Regulation of Energy and Glucose Homeostasis Henriette Kirchner Matthias Tschp Jenny Tong Chapter 8. Ghrelin Regulation of Sleep, Circadian Clock and Body Temperature va Szentirmai Levente Kaps Chapter 9. Ghrelin Regulation of Learning, Memory and Neurodegeneration Tamas L. Horvath Chapter 10. Ghrelin Antagonism: A Potential Therapeutic Target for Addictive Behavior Disorders Elisabet Jerlhag Emil Egecioglu Jrgen Engel Suzanne L. Dickson Chapter 11. Ghrelin Receptor Agonists in Cachexia of Human Aging Ralf Nass Michael O. Thorner Chapter 12. Use of Ghrelin and Ghrelin Receptor Agonists in Cancer- and Chemotherapy-Induced Cachexia Basil Burney Jose M. Garcia Chapter 13. Ghrelin in Cachexia Associated with End-Stage Renal Disease Damien Ashby Peter Choi Stephen Bloom Chapter 14. Ghrelin Suppression of Autoimmune Encephalomyelitis Sachiko Miyake Takashi Yamamura Chapter 15. Physiological Roles of Des-Acyl Ghrelin S.J.C.M.M. Neggers Riccarda Granata Ezio Ghigo Aart J. van der Lely
