Description
This book on NeuroAIDS, a collection of chapters written by experts and specialists from around the world, provides a global perspective on HIV and NeuroAIDS in the field, clinic, and laboratory. The chapters address the comorbidity of HIV and other infectious agents, including Zika virus, Ebola, Chagas disease, TB and HCV. Also discussed are key topics, such as: Molecular socioepidemiology Global HIV and NeuroAIDS Neuropathology cART and blood-brain barrier penetration HIV replicative oscillations HIV and SIV evolution Psychiatric comorbidities Neurosyphilis The examination of current and innovative models of translational research to translational effectiveness Paul Shapshak Division of Infectious Diseases and International Health Department of Internal Medicine University of South Florida Morsani College of Medicine Tampa, FL USA Andrew J. Levine Department of Neurology UCLA David Geffen School of Medicine Los Angeles, CA USA Brian T. Foley Theoretical Division Los Alamos National Laboratory Los Alamos, NM USA Charurut Somboonwit Division of Infectious Diseases and International Health Department of Internal Medicine University of South Florida Morsani College of Medicine Tampa, FL USA Elyse Singer Department of Neurology UCLA David Geffen School of Medicine Los Angeles, CA USA Francesco Chiappelli Department of Oral Biology and Medicine UCLA School of Dentistry Los Angeles, CA USA John T. Sinnott Division of Infectious Diseases and International Health Department of Internal Medicine University of South Florida Morsani College of Medicine Tampa, FL USA Forward Preface Chapter 1 Multidisciplinary Approach to HIV/AIDS: Historical Perspective Clyde B. McCoy*, A. Jeanene Bengoa*, Duane C. McBride, Brian T. Foley, Shikha Puri, Alejandro J. Mendez, and Paul Shapshak Chapter 2 Global Issues in NeuroAIDS Jennifer Massey* and Bruce Brew Chapter 3 HIV-1 related Central Nervous System Diseases: Pathogenesis, Diagnosis, and Treatment – An Indian Scenario Sudharsana Sundarrajan, Sajitha Lulu, and Mohanapriya Arumugam* Chapter 4 HIV-1 Diversity in Brazil Rodrigo Pessa and Sabri Saeed Sanabani* Chapter 5 HIV and SIV Evolution Brian T. Foley* Chapter 6 Human Brain Imaging in HIV and NeuroAIDS Mona A. Mohamed* and Peter Barker Chapter 7 HIV Neuroinvasion Suzanne Gartner* and Yiling Liu Chapter 8 Neuropathology of HIV-1 Disease Virawudh Soontornniyomkij* Chapter 9 HIV-related Peripheral Nervous System Illness Jocelyn Jiao, David M. Simpson, and Jessica Robinson-Papp* Chapter 10 The Role of Early Life Programming in Vulnerability and Resilience in Relation to HIV Luba Sominsky* and Deborah Hodgson Chapter 11 Neurocognition in Viral Suppressed HIV-Infected Children Claudia S. Crowell* and Kathleen Malee Chapter 12 Psychiatric Comorbidities in HIV-Infection April D. Thames* and Jacob D. Jones Chapter 13 Toward an Iterative Approach to Preventing HIV Risk Among Young MSM J. Bryan Page Chapter 14 NeuroAIDS in Drug Abusers – Associations with Oral Manifestations Fariba S. Younai* Chapter 15 Socioepidemiology of Injection Drug Users in Miami and HIV-1B Envelope (V1-V5) Genetic Diversity: A Preliminary Study Paul Shapshak*, Brian T. Foley, Seetharaman Balaji, David M. Segal, Clyde McCoy, and J. Bryan Page Chapter 16 The persistence of HIV associated neurocognitive disorder (HAND) in the era of combined antiretroviral therapy (cART) Elyse J. Singer* and Natasha M. Nemanim Chapter 17 Antiretroviral Therapy – Brain Penetration Charurut Somboonwit*, Jose A Montero, John T. Sinnott, and Paul Shapshak Chapter 18 Molecular Mechanisms of Cognitive Impairment in Patients with HIV Infection: Application of Bioinformatics and Data-Mining Luca Giacomelli*, Francesco Chiappelli, Bruno Orlando, Victor Sivozhelezov, and Roberto Eggenhffner Chapter 19 Genetic, Epigenetic, and Transcriptomic Studies of NeuroAIDS Andrew J. Levine*, Kumud K. Singh, Asha R. Kallianpur Chapter 20 NeuroAIDS: A Review of Gene Expression in Neurons, Astrocytes and Oligodendrocytes Jeanie McGee and Alireza Minagar* Chapter 21 Neuronal Apoptotic Pathways in HIV Associated Dementia, Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease Fatten F. Elkomy, Andrew J. Levine, Elyse Singer, Charurut Somboonwit, Todd Wills, Kaley Tash, John T. Sinnott, Sally Alrabaa, Anteneh Addisu, Hector Rodriguez, Francesco Chiappelli, Toni Kazic, and Paul Shapshak* Chapter 22 Clinical Relevance of Humanized Mice Rachel Samantha Resop, Irene Jane Kim, Huy Nguyen, and Dimitrios Nikolaos Vatakis* Chapter 23 HIV and Stroke Souvik Sen*, Lauren Giamberardino, and Parth Thakker Chapter 24 Hepatitis C and HIV Neurological Implications Shuchi Pandya, Misbahuddin Syed, Manuel Castro, Jamie P. Morano, and Beata Casanas* Chapter 25 Central Nervous System Reactivation of Chagas Disease in Immuno-compromised Patients with HIV/AIDS Silvana Maria Eloi-Santos*, Unai Tupinambs, Helena Duani, and Jose Eymard Homem Pittella Chapter 26 Central Nervous System Tuberculosis Beata Casanas*, Douglas Holt, and Kelly Kynaston Chapter 27 Neurosyphilis and HIV infection Anteneh Addisu, Beata C Casanas, and Sally Alrabaa Chapter 28 Orthopoxviruses and Human Disease Robert Castro and Beata Casanas* Chapter 29 Opportunistic Neurologic Infections in Patients Infected with Human Immunodeficiency Virus Kelly Kynaston, Minh Ho, Robert Castro, and Jose Montero* Chapter 30 Zika Virus and HIV/AIDS A. Jeanene Bengoa*, Clyde B. McCoy*, Brian T. Foley, Shikha Puri, Alejandro J. Mendez, and Paul Shapshak Chapter 31 Global Convergent Translational Science for Neuro-Involvement in Ebola Viral Disease: Lessons Learned from Neuro-AIDS Francesco Chiappelli*, Allen M. Khakshooy, Andre Barkhordarian, Vandan R. Kasar, Melissa Nahcivan, Mia T. Nguyen, Jeong Min (Grace) Hwang, Marena Martinez Kutschman, Angela Du, and Nashwa Softo Chapter 32 Sequence Accuracy in Primary Databases: A case study on HIV-1B Seetharaman Balaji*, Ramachandran Akash, Nandy Krittika, and Paul Shapshak Chapter 33 Amyloidogenic Pattern Prediction of HIV-1 Proteins Patil Sneha, Seetharaman Balaji*, and Paul Shapshak Chapter 34 On the Potential for Multiscale Oscillatory Behavior in HIV Alexander V. Ratushny*, Patrick De Leenheer, Sergei I. Bazhan, Gennady A. Bocharov, Tamara M. Khlebodarova, and Vitaly A. Likhoshvai Chapter 35 Short oligo-peptide T-cell epitopes in HIV-1/AIDS vaccine development: Current status, design, promises and challenges Pandjassarame Kangueane*, Kumar Viswapoorani, Christina Nillofer, Subramani Manimegalai, Murugan Sivagamy, Uma Kangueane, Gopichandran Sowmya, and Meena Kishore Sakharkar Chapter 36 HIV-1 Envelope (ENV) GP160 trimer protein complex SPIKE as a recombinant macro-molecular assembly vaccine component candidate – Current opinion Christina Nilofer, Arumugam Mohanapriya, and Pandjassarame Kangueane* Chapter 37 Gene Therapy Blueprints for NeuroAIDS Hector E. Rodriguez, Seetha Lakshmi, Charurut Somboonwit, Asa Oxner, Lucy Guerra, Anteneh Addisu, Louise Gutierrez, John T. Sinnott, Christina Nilofer, Pandjassarame Kangueane, and Paul Shapshak* Chapter 38 Biostatistical Concerns in HIV Research Robert C. Duncan*
