Description
1. Historical view Section I: Pathophysiology of prions 2. The cellular and pathological prion protein 3. Cell biology of prion infection 4. Experimental models of human prion diseases and prion strains 5. The role of the immune system in prion infection Section II: Animal prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes) 6. Typical and atypical scrapie 7. Typical and atypical BSE 8. Chronic Wasting Disease Section III: Human prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes) 9. Sporadic Creutzfeldt-Jakob Disease 10. Variably protease-sensitive prionopathy 11. Variant Creutzfeldt-Jakob Disease 12. Iatrogenic Creutzfeldt-Jakob Disease 13. Genetic Creutzfeldt-Jakob Disease 14. Gerstmann-Strussler-Scheinker disease 15. Sporadic and fatal Familial Insomnia Section IV: Prion-like mechanisms in other neurodegenerative diseases 16. Prion-like mechanisms in Alzheimer 17. Prion-like mechanisms in Parkinson 18. Prion-like mechanisms in ALS Section V: Diagnosis and treatment 19. Prion protein amplification techniques 20. Differential diagnosis with other rapid progressive dementias 21. Symptomatic treatment, care and support of CJD patients 22. Identifying therapeutic targets and treatment in model systems 23. Vaccination strategies 24. Clinical trials Section VI: Public health issues 25. Animal diseases and the zoonotic potential 26. Safety of blood, blood derivatives and plasma-derived products 27. Safety in clinical practice 28. Concluding thoughts
