Description
Introduction: What is ROS? The generation of hydrogen peroxide in biology. The neutrophil NADPH oxidase. The NOX enzymes. Mitochondrial oxidant production. Hydrogen peroxide generation in high oxygen conditions. Hydrogen peroxide generation in inflammation. Proteins that metabolise and utilise hydrogen peroxide. Hemoglobin. Myeloperoxidase. Eosinophil peroxidise. Catalase. Glutathione peroxidise. The biological consequences of hydrogen peroxide production. Hydrogen peroxide in inflammation. Protein peroxides. The generation of hypohalous acids. Hydrogen peroxide mediated signalling. Antioxidant protection against hydrogen peroxide thiol chemistry. The Glutathione system. Thioredoxin system. Peroxiredoxins
