Description
This volume discusses experimental brain injury models that contain valuable information carefully chosen to widen the researchers’ horizon about neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have been adapted and made ready for application in laboratory settings. For easier navigation, the chapters are categorized into 6 parts: Introduction, General Consideration in Using Animal Laboratory in CNS Injury Research, Classical TBI Models and Their Link with Pathophysiological Features of CBS Injury – Models, Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, Outcome Measures in Brain Injury Models, and Future Directions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards the progress of this discipline. Part I Introduction 1. The History and Evolution of Experimental Traumatic Brain Injury Models John Povlishock Part II. General Consideration in Using Animal Laboratory in CNS Injury Research 2. Clinical Traumatic Brain Injury in the Preclinical Setting Justin Berkner, Rebekah Mannix, and Jianhua Qiu 3. Rodent Models of Traumatic Brain Injury: Methods and Challenges Niklas Marklund 4. Traumatic Brain Injury Models in Animals Elham Rostami 5. Systematic Review of Traumatic Brain Injury Animal Models Helen W. Phipps 6. Methods of Drug Delivery in Neurotrauma Ying Deng-Bryant, Ryan Readnower, Lai Yee Leung, Frank Tortella, and Deborah Shear 7. Bridging the Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental Testing Pamela J. VandeVord, Alessandra Dal Cengio Leonardi, and David Ritzel 8. Cellular Mechanisms and Behavioral Outcomes in Blast-Induced Neurotrauma: Comparing Experimental Set-Ups Zachary S. Bailey, William Brad Hubbard, and Pamela J. VandeVord 9. Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics for Traumatic Brain Injury Zaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou Abbass, and Firas Kobeissy 10. Role of Systems Biology in Brain Injury Biomarker Discovery: A Neuroproteomic Application Zaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou Abbass, Hiba Ghandour, Stefania Mondello, and Firas Kobeissy Part III Classical TBI Models and Their Link with Pathophysiological Features of CNS Injury – Models 11. The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol Nicole Osier and C. Edward Dixon 12. Weight Drop Models in Traumatic Brain Injury Brian T. Kalish and Michael J. Whalen 13. Midline (Central) Fluid Percussion Model of Traumatic Brain Injury Rachel K. Rowe, Daniel R. Griffiths, and Jonathan Lifshitz 14. Lateral (Parasagittal) Fluid Percussion Model of Brain Injury Ken C. Van and Bruce G. Lyeth 15. Impact Acceleration Model of Diffuse Traumatic Brain Injury Sarah C. Hellewell, Jenna M. Ziebell, Jonathan Lifshitz, and M. Cristina Morganti-Kossmann 16. Experimental Models for Neurotrauma Research Johan Davidsson and Mrten Risling iv =”” special=”” topics=”” in=”” cns=”” trauma:=”” comorbid=”” conditions=”” injury 22. Combined Neurotrauma Models: Experimental Models Combining Traumatic Brain Injury and Secondary Insults Dennis W. Simon, Vincent M. Vagni, Patrick M. Kochanek, and Robert S. B. Clark 23. Microdialysis as Clinical Evaluation of Therapeutic Hypothermia in Rat Subdural Hematoma Model Shoji Yokobori, Markus S. Spurlock, Stephanie W. Lee, Shyam Gajavelli, and Ross M. Bullock 24. Repetitive Transcranial Magnetic Stimulation as a Novel Therapy in Animal Models of Traumatic Brain Injury Thangavelu Soundara Rajan, Salvatore Cuzzocrea, Daniele Bruschetta, and Angelo Quartarone 25. Experimental Models Combining TBI, Hemorrhagic Shock, and Hypoxemia Lai Yee Leung, Ying Deng-Bryant, Deborah Shear, and Frank Tortella 26. Experimental Models Combining Traumatic Brain Injury and Hypoxia Eric P. Thelin 27. Animal Models of Post-Traumatic Seizures and Epilepsy Alexander V. Glushakov, Olena Y. Glushakova, Sylvain Dor, Paul R. Carney, and Ronald L. Hayes 28. Closed-Head TBI Model of Multiple-Morbidity Floyd J. Thompson, Jiamei Hou, and Prodip K. Bose Part V Outcome Measures in Brain Injury Models 29. Cognitive Evaluation Using Morris Water Maze in Neurotrauma Ying Deng-Bryant, Lai Yee Leung, Krista Caudle, Frank Tortella, and Deborah Shear 30. Assessment of Cognitive Function in the Water Maze Task: Maximizing Data Collection and Analysis in Animal Models of Brain Injury Mark D. Whiting and Olga N. Kokiko-Cochran 31. Detecting Behavioral Deficits Post Traumatic Brain Injury in RatsHibah O. Awwad 32. Advanced and High Throughput Method for Mitochondrial Bioenergetics Evaluation in Neurotrauma Jignesh D. Pandya, Patrick G. Sullivan, Lai Yee Leung, Frank C. Tortella, Deborah A. Shear, and Ying Deng-Bryant 33. Determination of Vascular Reactivity of Middle Cerebral Arteries from Stroke and Spinal Cord Injury Animal Models Using Pressure Myography Mohammad A. Anwar and Ali H. Eid 34. Assessment of Basilar Artery Reactivity in Stroke and Subarachnoid Hemorrhage Using Wire Myograph Crystal M. Ghantous, Zeina Azrak, Farah Abdel Rahman, Hana A. Itani, and Asad Zeidan 35. Magnetic Resonance Imaging in Experimental Traumatic Brain Injury Qiang Shen, Lora Tally Watts, Wei Li, and Timothy Q. Duong 36. A Simplified Workflow for Protein Quantitation of Rat Brain Tissues Using Label-Free Proteomics and Spectral Counting Angela M. Boutt, Shonnette F. Grant, and Jitendra R. Dave 37. Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury Hassan Al-Ali, Vance P. Lemmon, and John L. Bixby 38. Postnatal Neural Stem Cells in Treating Traumatic Brain Injury Hussein Gazalah, Sarah Mantash, Naify Ramadan, Sawsan Al Lafi, Sally El Sitt, Hala Darwish, Hassan Azari, Lama Fawaz, Nol Ghanem, Kazem Zibara, Rose-Mary Boustany, Firas Kobeissy, and Jihane Soueid 39. A Novel Biopsy Method for Isolating Neural Stem Cells from the Subventricular Zone of the Adult Rat Brain for Autologous Transplantation in CNS Injuries Hadi Aligholi, Gholamreza Hassanzadeh, Ali Gorji, and Hassan Azari Part VI Future Directions 40. Challenging the Paradigms of Experimental TBI Models: From Preclinical to Clinical Practice Frank Tortella
