Description
Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance. The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques. The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents. Written in the successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies. 1. An Introduction to Drug Testing – The Expanding Role of Mass Spectrometry Catherine Hammett-Stabler and Steven W. Cotton 2. LC-MS vs. GC-MS, Online Extraction Systems, Advantages of Technology for Drug Screening Assays Pierre Marquet 3. LC-MS/MS Techniques for High Volume Screening of Drugs of Abuse and Target Drug Quantitation in Urine/Blood Matrices Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay 4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda 5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay 6. Synthetic Opioid Analysis by LC-MS/MS David M. Garby and Lynn A. Cheryk 7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection Oscar Quintela and Dennis J. Crouch 8. Cocaine and Metabolites by LC-MS/MS Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman 9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS Robert A. Middleberg and Joseph Homan 10. Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch 11. LC-MS/MS Screen for Xenobiotics and Metabolites Franois-Ludovic Sauvage and Pierre Marquet 12. Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS Robert A. Middleberg and Joseph Homan 13. Hypoglycemic Agent Screening by LC-MS/MS Eric W. Korman, Loralie J. Langman, and Christine L. H. Snozek 14. LC-MS/MS Method for the Detection of Common Laxatives Robert A. Middleberg and Joseph Homan 15. Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS) Uttam Garg, Ada Munar, and C. Clinton Frazee III 16. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, and Gwendolyn A. McMillin 17. Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS Elizabeth R. Kiely and Heather M. Antonides 18. Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry Jennifer A. Collins and Gregory C. Janis 19. Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay 4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda 5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay 6. Synthetic Opioid Analysis by LC-MS/MS David M. Garby and Lynn A. Cheryk 7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection Oscar Quintela and Dennis J. Crouch 8. Cocaine and Metabolites by LC-MS/MS Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman 9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS Robert A. Middleberg and Joseph Homan 10. Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch 11. LC-MS/MS Screen for Xenobiotics and Metabolites Franois-Ludovic Sauvage and Pierre Marquet 12. Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS Robert A. Middleberg and Joseph Homan 13. Hypoglycemic Agent Screening by LC-MS/MS Eric W. Korman, Loralie J. Langman, and Christine L. H. Snozek 14. LC-MS/MS Method for the Detection of Common Laxatives Robert A. Middleberg and Joseph Homan 15. Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS) Uttam Garg, Ada Munar, and C. Clinton Frazee III 16. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, and Gwendolyn A. McMillin 17. Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS Elizabeth R. Kiely and Heather M. Antonides 18. Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry Jennifer A. Collins and Gregory C. Janis 19. Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay 4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda 5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay 6. Synthetic Opioid Analysis by LC-MS/MS David M. Garby and Lynn A. Cheryk 7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection Oscar Quintela and Dennis J. Crouch 8. Cocaine and Metabolites by LC-MS/MS Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman 9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS Robert A. Middleberg and Joseph Homan 10. Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch 11. LC-MS/MS Screen for Xenobiotics and Metabolites Franois-Ludovic Sauvage and Pierre Marquet 12. Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS Robert A. Middleberg and Joseph Homan 13. Hypoglycemic Agent Screening by LC-MS/MS Eric W. Korman, Loralie J. Langman, and Christine L. H. Snozek 14. LC-MS/MS Method for the Detection of Common Laxatives Robert A. Middleberg and Joseph Homan 15. Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS) Uttam Garg, Ada Munar, and C. Clinton Frazee III 16. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, and Gwendolyn A. McMillin 17. Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS Elizabeth R. Kiely and Heather M. Antonides 18. Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry Jennifer A. Collins and Gregory C. Janis 19. Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay 4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda 5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay 6. Synthetic Opioid Analysis by LC-MS/MS David M. Garby and Lynn A. Cheryk 7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection Oscar Quintela and Dennis J. Crouch 8. Cocaine and Metabolites by LC-MS/MS Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman 9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS Robert A. Middleberg and Joseph Homan 10. Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch 11. LC-MS/MS Screen for Xenobiotics and Metabolites Franois-Ludovic Sauvage and Pierre Marquet 12. Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS Robert A. Middleberg and Joseph Homan 13. Hypoglycemic Agent Screening by LC-MS/MS Eric W. Korman, Loralie J. Langman, and Christine L. H. Snozek 14. LC-MS/MS Method for the Detection of Common Laxatives Robert A. Middleberg and Joseph Homan 15. Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS) Uttam Garg, Ada Munar, and C. Clinton Frazee III 16. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, and Gwendolyn A. McMillin 17. Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS Elizabeth R. Kiely and Heather M. Antonides 18. Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry Jennifer A. Collins and Gregory C. Janis 19. Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu
