Description
Management of Soft Tissue Sarcoma, 2nd Edition provides the most comprehensive analysis of demographics and natural history currently available for these lesions, based on the authors’ experience with over 10,000 patients. Sections regarding radiation therapy not found in the previous text have been expanded, as have updates on molecular characteristics of sarcomas and chemotherapy studies published since the prior edition. Clinical and molecular diagnoses are addressed, and tumor histopathology is employed as the basis of treatment recommendations including surgery, radiation and systemic therapy. This is the first book to provide specific chemotherapy opinions for every sarcoma subtype. Written by four world-renowned experts, this book gives a practical, up-to-date approach to managing the many subtypes of adult soft tissue sarcoma. Reviews from the first edition: “This is an impressive book. Written by a surgeon, a pathologist and an oncologist, the book draws heavily on the Memorial Sloan-Kettering Cancer Center soft tissue sarcoma (STS) database. … it is a book that should be in the library of any sarcoma unit and will appeal to the sub-specialist in Orthopaedic Oncology.” (Robert U. Ashford, European Journal of Orthopaedic Surgery & Traumatology, Vol. 24, 2014) “The book is laid out in 27 chapters, with an impressive inclusion of a wide array of sarcoma histology. One of the real strengths of the book is the quality and number of images, figures, tables, and graphs. … The overall outline of the text is well done. … This book is a unique and important addition to the sarcoma literature. … this edtion should find itself on every medical oncologist’s bookshelf … .” (Larry C. Daugherty and Sanjay P. Bagaria, Journal of Radiation Oncology, Vol. 3, 2014) Murray F. Brennan, MDInternational Center & Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew York, NYCristina R. Antonescu, MDDepartment of PathologyMemorial Sloan-Kettering Cancer CenterNew York, NYKaled M. Alektiar, MDDepartment of Radiation OncologyMemorial Sloan-Kettering Cancer CenterNew York, NYRobert G. Maki, MD, PhDGreat Neck, NYCold Spring Harbor Laboratory Cold Spring Harbor, NY Management of Soft Tissue Sarcoma Table of Contents Preface Part I Introduction 1. General Description Introduction Incidence and Prevalence Predisposing and Genetic Factors References 2. Natural History – Importance of Size, Site, Histopathology Natural History Influence of Site Staging Staging of Retroperitoneal Visceral Sarcoma Prognostic Factors for Extremity and Superficial Soft Tissue Sarcoma Disease-Specific Survival Prognostic Factors for Survival Following Local Recurrence of Extremity Sarcoma Prognostic Factors: Nomograms References 3. General Statement as to Efficacy Surgery / Chemotherapy / Radiation Therapy Extent of primary surgery Surgical Treatment of Local Recurrence Diagnostic Imaging Surgery for Metastatic Disease o Pulmonary Metastasis o Surgery and the Management of Sarcoma Liver Metastasis Radiation Therapy o Adjuvant Radiation Therapy o Dose of Radiation Therapy o Adjuvant Brachytherapy o Radiation Therapy in the Presence of Positive Microscopic Margins o Definitive Radiation Therapy o Radiation to Patients with Neurovascular Involvement o Wound Complications of Radiation Therapy o Adjuvant and Neoadjuvant Chemotherapy for Soft Tissue Sarcomas o Sarcomas More Common in Adults o Larger Randomized Studies o Selected Meta-analyses of Randomized Trials of Adjuvant Chemotherapy o Adjuvant Therapy for GIST o Sarcomas More Common in Pediatric Setting o Brief comments regarding chemotherapy for metastatic soft tissue sarcoma o Newer Systemic Agents Special Techniques for Primary & Locally Recurrent Disease o Intra-arterial Chemotherapy o Limb Perfusion and Hyperthermia o Immunotherapy for Sarcomas
