Description
Since its first application, microdialysis has become incredibly popular to study brain function and has been applied with success in different fields from psychopharmacology, neurobiology, and physiology in animals and also humans. Microdialysis Techniques in Neuroscience focuses on the practical aspects of microdialysis in animal and human, highlighting current technical limitations and providing a vision of what is yet to come for the determination of the most disparate compounds in the brain. The book’s contents range from new techniques for detection and quantifying the release of several different neurotransmitters in vitro and in vivo, even in freely moving animals, to sophisticated use of reverse dialysis and the application of microdialysis in pharmacokinetic studies. Each of the sixteen chapters, in fitting with the spirit of the Neuromethods series, contain an introduction that gives a broad overview of a focused topic, followed by an extensive protocol on how the experiments are performed along with invaluable practical advice. Detailed and authoritative, Microdialysis Techniques in Neuroscience will be a valuable reference for students, neuroscientists, and physicians for the use of microdialysis in the study of brain functions and its clinical applications. 1. Cerebral Microdialysis: Research Technique or Clinical Tool? Anouk Borg and Martin Smith 2. In Vivo Microdialysis to Study Striatal Dopaminergic Neurodegeneration Giuseppe Di Giovanni, Massimo Pierucci, Mauro Pessia, and Vincenzo Di Matteo 3. Application of Reverse Microdialysis in Neuropharmacological Studies Christian Hcht, Facundo Martn Bertera, and Carlos Alberto Taira 4. Microdialysis and Advances for Sampling Synaptic and Extrasynaptic Pools Cheng-fu Chen, Brian T. Rasely, Benjamin P.E. Warlick, Tom K. Green, Kristian E. Swearingen, and Kelly L. Drew 5. In Vivo Microdialysis for Measurement of Oxidative Metabolism in the Living Brain H. Ronald Zielke, Carol L. Zielke, and Peter J. Baab 6. Quantitative In Vivo Microdialysis in Pharmacokinetic Studies Teodoro Zornoza, Mara Jos Cano-Cebrin, Ana Polache, and Luis Granero 7. Combination of In Vivo Microdialysis with Selective Electrochemical Detection for Online Continuously Monitoring Brain Chemistry Yuqing Lin, Zipin Zhang, and Lanqun Mao 8. Application of Spinal Microdialysis in Freely Moving Rats Vincent Umbrain, Lin Shi, Jan Poelaert, and Ilse Smolders 9. Monitoring Extracellular Monoamines with In Vivo Microdialysis in Awake Rats: A Practical Approach Roberto W. Invernizzi 10. Intracerebral Human Microdialysis in Parkinson’s Disease Salvatore Galati and Giuseppe Di Giovanni 11. Monitoring Extracellular Amino Acid Neurotransmitters and hROS by In Vivo Microdialysis in Rats: A Practical Approach Maria Alessandra Colivicchi, Chiara Stefanini, Wolfhardt Freinbichler, Chiara Ballini, Loria Bianchi, Keith F. Tipton, and Laura Della Corte 12. Measurement of Neuropeptides in Dialysate by LC-MS Omar S. Mabrouk and Robert T. Kennedy 13. Achieving High Temporal Resolution for In Vivo Measurements by Microdialysis Neil D. Hershey and Robert T. Kennedy 14. Indirect Analysis of Nitric Oxide and Quantitation of Selective Nitric Oxide Synthase Inhibitors in Microdialysate Samples Gary M. Pollack 15. Determination of Histamine in Microdialysis Samples from the Rodent Brain by Column Liquid Chromatography Jan Kehr and Takashi Yoshitake 16. Intracerebral Microdialysis in the Study of Limbic Seizure Mechanisms and Antiepileptic Drug Action Using Freely Moving Rats Jeanelle Portelli and Ilse Smolders Anouk Borg and Martin Smith 2. In Vivo Microdialysis to Study Striatal Dopaminergic Neurodegeneration Giuseppe Di Giovanni, Massimo Pierucci, Mauro Pessia, and Vincenzo Di Matteo 3. Application of Reverse Microdialysis in Neuropharmacological Studies Christian Hcht, Facundo Martn Bertera, and Carlos Alberto Taira 4. Microdialysis and Advances for Sampling Synaptic and Extrasynaptic Pools Cheng-fu Chen, Brian T. Rasely, Benjamin P.E. Warlick, Tom K. Green, Kristian E. Swearingen, and Kelly L. Drew 5. In Vivo Microdialysis for Measurement of Oxidative Metabolism in the Living Brain H. Ronald Zielke, Carol L. Zielke, and Peter J. Baab 6. Quantitative In Vivo Microdialysis in Pharmacokinetic Studies Teodoro Zornoza, Mara Jos Cano-Cebrin, Ana Polache, and Luis Granero 7. Combination of In Vivo Microdialysis with Selective Electrochemical Detection for Online Continuously Monitoring Brain Chemistry Yuqing Lin, Zipin Zhang, and Lanqun Mao 8. Application of Spinal Microdialysis in Freely Moving Rats Vincent Umbrain, Lin Shi, Jan Poelaert, and Ilse Smolders 9. Monitoring Extracellular Monoamines with In Vivo Microdialysis in Awake Rats: A Practical Approach Roberto W. Invernizzi 10. Intracerebral Human Microdialysis in Parkinson’s Disease Salvatore Galati and Giuseppe Di Giovanni 11. Monitoring Extracellular Amino Acid Neurotransmitters and hROS by In Vivo Microdialysis in Rats: A Practical Approach Maria Alessandra Colivicchi, Chiara Stefanini, Wolfhardt Freinbichler, Chiara Ballini, Loria Bianchi, Keith F. Tipton, and Laura Della Corte 12. Measurement of Neuropeptides in Dialysate by LC-MS Omar S. Mabrouk and Robert T. Kennedy 13. Achieving High Temporal Resolution for In Vivo Measurements by Microdialysis Neil D. Hershey and Robert T. Kennedy 14. Indirect Analysis of Nitric Oxide and Quantitation of Selective Nitric Oxide Synthase Inhibitors in Microdialysate Samples Gary M. Pollack 15. Determination of Histamine in Microdialysis Samples from the Rodent Brain by Column Liquid Chromatography Jan Kehr and Takashi Yoshitake 16. Intracerebral Microdialysis in the Study of Limbic Seizure Mechanisms and Antiepileptic Drug Action Using Freely Moving Rats Jeanelle Portelli and Ilse Smolders Giuseppe Di Giovanni, Massimo Pierucci, Mauro Pessia, and Vincenzo Di Matteo 3. Application of Reverse Microdialysis in Neuropharmacological Studies Christian Hcht, Facundo Martn Bertera, and Carlos Alberto Taira 4. Microdialysis and Advances for Sampling Synaptic and Extrasynaptic Pools Cheng-fu Chen, Brian T. Rasely, Benjamin P.E. Warlick, Tom K. Green, Kristian E. Swearingen, and Kelly L. Drew 5. In Vivo Microdialysis for Measurement of Oxidative Metabolism in the Living Brain H. Ronald Zielke, Carol L. Zielke, and Peter J. Baab 6. Quantitative In Vivo Microdialysis in Pharmacokinetic Studies Teodoro Zornoza, Mara Jos Cano-Cebrin, Ana Polache, and Luis Granero 7. Combination of In Vivo Microdialysis with Selective Electrochemical Detection for Online Continuously Monitoring Brain Chemistry Yuqing Lin, Zipin Zhang, and Lanqun Mao 8. Application of Spinal Microdialysis in Freely Moving Rats Vincent Umbrain, Lin Shi, Jan Poelaert, and Ilse Smolders 9. Monitoring Extracellular Monoamines with In Vivo Microdialysis in Awake Rats: A Practical Approach Roberto W. Invernizzi 10. Intracerebral Human Microdialysis in Parkinson’s Disease Salvatore Galati and Giuseppe Di Giovanni 11. Monitoring Extracellular Amino Acid Neurotransmitters and hROS by In Vivo Microdialysis in Rats: A Practical Approach Maria Alessandra Colivicchi, Chiara Stefanini, Wolfhardt Freinbichler, Chiara Ballini, Loria Bianchi, Keith F. Tipton, and Laura Della Corte 12. Measurement of Neuropeptides in Dialysate by LC-MS Omar S. Mabrouk and Robert T. Kennedy 13. Achieving High Temporal Resolution for In Vivo Measurements by Microdialysis Neil D. Hershey and Robert T. Kennedy 14. Indirect Analysis of Nitric Oxide and Quantitation of Selective Nitric Oxide Synthase Inhibitors in Microdialysate Samples Gary M. Pollack 15. Determination of Histamine in Microdialysis Samples from the Rodent Brain by Column Liquid Chromatography Jan Kehr and Takashi Yoshitake 16. Intracerebral Microdialysis in the Study of Limbic Seizure Mechanisms and Antiepileptic Drug Action Using Freely Moving Rats Jeanelle Portelli and Ilse Smolders Christian Hcht, Facundo Martn Bertera, and Carlos Alberto Taira 4. Microdialysis and Advances for Sampling Synaptic and Extrasynaptic Pools Cheng-fu Chen, Brian T. Rasely, Benjamin P.E. Warlick, Tom K. Green, Kristian E. Swearingen, and Kelly L. Drew 5. In Vivo Microdialysis for Measurement of Oxidative Metabolism in the Living Brain H. Ronald Zielke, Carol L. Zielke, and Peter J. Baab 6. Quantitative In Vivo Microdialysis in Pharmacokinetic Studies Teodoro Zornoza, Mara Jos Cano-Cebrin, Ana Polache, and Luis Granero 7. Combination of In Vivo Microdialysis with Selective Electrochemical Detection for Online Continuously Monitoring Brain Chemistry Yuqing Lin, Zipin Zhang, and Lanqun Mao 8. Application of Spinal Microdialysis in Freely Moving Rats Vincent Umbrain, Lin Shi, Jan Poelaert, and Ilse Smolders 9. Monitoring Extracellular Monoamines with In Vivo Microdialysis in Awake Rats: A Practical Approach Roberto W. Invernizzi 10. Intracerebral Human Microdialysis in Parkinson’s Disease Salvatore Galati and Giuseppe Di Giovanni 11. Monitoring Extracellular Amino Acid Neurotransmitters and hROS by In Vivo Microdialysis in Rats: A Practical Approach Maria Alessandra Colivicchi, Chiara Stefanini, Wolfhardt Freinbichler, Chiara Ballini, Loria Bianchi, Keith F. Tipton, and Laura Della Corte 12. Measurement of Neuropeptides in Dialysate by LC-MS Omar S. Mabrouk and Robert T. Kennedy 13. Achieving High Temporal Resolution for In Vivo Measurements by Microdialysis Neil D. Hershey and Robert T. Kennedy 14. Indirect Analysis of Nitric Oxide and Quantitation of Selective Nitric Oxide Synthase Inhibitors in Microdialysate Samples Gary M. Pollack 15. Determination of Histamine in Microdialysis Samples from the Rodent Brain by Column Liquid Chromatography Jan Kehr and Takashi Yoshitake 16. Intracerebral Microdialysis in the Study of Limbic Seizure Mechanisms and Antiepileptic Drug Action Using Freely Moving Rats Jeanelle Portelli and Ilse Smolders Teodoro Zornoza, Mara Jos Cano-Cebrin, Ana Polache, and Luis Granero 7. Combination of In Vivo Microdialysis with Selective Electrochemical Detection for Online Continuously Monitoring Brain Chemistry Yuqing Lin, Zipin Zhang, and Lanqun Mao 8. Application of Spinal Microdialysis in Freely Moving Rats Vincent Umbrain, Lin Shi, Jan Poelaert, and Ilse Smolders 9. Monitoring Extracellular Monoamines with In Vivo Microdialysis in Awake Rats: A Practical Approach Roberto W. Invernizzi 10. Intracerebral Human Microdialysis in Parkinson’s Disease Salvatore Galati and Giuseppe Di Giovanni 11. Monitoring Extracellular Amino Acid Neurotransmitters and hROS by In Vivo Microdialysis in Rats: A Practical Approach Maria Alessandra Colivicchi, Chiara Stefanini, Wolfhardt Freinbichler, Chiara Ballini, Loria Bianchi, Keith F. Tipton, and Laura Della Corte 12. Measurement of Neuropeptides in Dialysate by LC-MS Omar S. Mabrouk and Robert T. Kennedy 13. Achieving High Temporal Resolution for In Vivo Measurements by Microdialysis Neil D. Hershey and Robert T. Kennedy 14. Indirect Analysis of Nitric Oxide and Quantitation of Selective Nitric Oxide Synthase Inhibitors in Microdialysate Samples Gary M. Pollack 15. Determination of Histamine in Microdialysis Samples from the Rodent Brain by Column Liquid Chromatography Jan Kehr and Takashi Yoshitake 16. Intracerebral Microdialysis in the Study of Limbic Seizure Mechanisms and Antiepileptic Drug Action Using Freely Moving Rats Jeanelle Portelli and Ilse Smolders
