Description
Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity. Preface Part I MicroRNAs: biology and implications in cancer 1 MicroRNAs and cancer: an overview Sadegh Babashah 2 Epigenetics and microRNA in cancer Jiazeng Xia, Xiaoqiang Guo, Kaiyuan Deng 3 MicroRNA, diet and cancer chemoprevention Sharanjot Saini, Rajvir Dahiya 4 MicroRNAs and energy metabolism in cancer cells Linchong Sun, Xiaoping He, Yang Cao, Ping Gao, Huafeng Zhang 5 MicroRNAs and solid tumors Gianpiero Di Leva, Michela Garofalo 6 MicroRNAs and blood cancers Charles H Lawrie 7 MicroRNAs and oncogenic human viruses Muriel Thirion, Teru Kanda, Yoshiki Murakami, Takahiro Ochiya, Hisashi Iizasa 8 MicroRNAs linking cancer and inflammation: focus on liver cancer Anglique Gougelet and Sabine Colnot 9 MicroRNAs and regulatory pathways in tumorigenesis Jun Wei, Yong Li, Xiaoming Liu, William C. Cho 10 MicroRNA-modulated apoptotic and autophagic signaling networks in cancer Bo Liu, Yu-quan Wei 11 MicroRNAs and cancer drug resistance and drug sensitivity Hugo Seca, Raquel T. Lima, M. Helena Vasconcelos 12 The biological roles of microRNAs in cancer stem cells Bin Bao, Asfar S. Azmi, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Shadan Ali, and Fazlul H. Sarkar Part II MicroRNAs and their clinical implications 13 MicroRNAs and clinical implications in cancer Jrgen Wittmann 14 MicroRNA expression profiling and its clinical impact in breast cancer Manuela Ferracin, Laura Lupini 15 MicroRNAs and their clinical impact on resistance to anticancer treatment Kirsten Lindner, Joerg Haier, Richard Hummel 16 Nanocarriers and microRNA-based scenarios for cancer therapy Babak Bakhshinejad, Mohammad Amin Javidi, Sahar Babashah, Sadegh Babashah 17 Challenges and strategies for pulmonary delivery of microRNA-based therapeutics Yu Fujita, Kazuyoshi Kuwano ,Takahiro Ochiya Abbreviations Index
