Description
State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters. Part 1: Mechanisms of Brain Defense and Neuropathogenesis Chapter 1: The Blood Brain Barrier Victor Castro, Michal Toborek Chapter 2: Immune Cell Trafficking in the Central Nervous System Beena John, Christopher A. Hunter, Tajie H. Harris Chapter 3: General Physiology and Pathophysiology of Microglia Alexei Verkhratsky, Mami Noda Chapter 4: Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases Gordon P. Meares, Etty N. Benveniste Chapter 5: Oxidative stress, neuroinflammation, and neurodegeneration Hui-Ming Gao, Hui Zhou, Jau-Shyong Hong Chapter 6: Peripheral Neuroimmune Interactions and Neuropathic Pain Halina Machelska Part 2: Neurological Diseases and Inflammation Chapter 7: Innate and Adaptive Immune-Mediated Neuroinflammation and Neurodegeneration in Parkinson’s Disease Rebecca A. Wilshusen, R. Lee Mosley Chapter 8: Multiple sclerosis: impact on functioning of the blood-brain barrier Mark R. Mizee, Gijs Kooij, Helga E. de Vries Chapter 9: Neuroinflammation in Alzheimer’s disease Veronika M. Reinisch, Daniela L. Krause, Norbert Mller Chapter 10: Neuroinflammation in Huntington’s Disease Roland G. W. Staal, Thomas Mller Chapter 11: Neuroinflammation and immune regulation in ischemic stroke: identification of new pharmacological targets Mario Di Napoli, Craig J. Smith, Stephen J. Hopkins, Aurel Popa-Wagner, Ana Maria Buga, Mark Slevic Part 3: Infectious Diseases Chapter 12: HIV/NeuroAIDS Kelly Stauch, Howard S. Fox Chapter 13: Herpes Simplex Virus Infections Of The Central Nervous System Richard J. Whitley Chapter 14: Congenital Cytomegalovirus Disease Mark R. Schleiss Chapter 15: Japanese Encephalitis: A Tale of Inflammation and Degeneration in the Central Nervous System Kallol Dutta, Anirban Basu Chapter 16: The biology and clinical consequence of infection with the human polyomavirus JCV G. von Geldern, M. J. Barhams, E.O. Major Chapter 17: Role of Retrovirus-Induced Transactivator Proteins in Neuroinflammatory Disease Gregory Antell, Michael R. Nonnemacher, Vanessa Pirrone, Brian Wigdahl Chapter 18: Immunopathogenesis of bacterial meningitis Uwe Koedel, Matthias Klein, Hans-Walter Pfister Chapter 19: Cerebral Malaria Gregory S. Park, Chandy C. John Part 4: Drugs of Abuse and NeuroAIDS Chapter 20: HIV and Cocaine Interplay in HIV-associated Neurocognitive Disorders Honghong Yao, Crstal Bethel-Brown, Shilpa Buch Chapter 21: Methamphetamine Neurotoxicity and Neuroinflammatory Processes Nicole A. Northrop, Bryan K. Yamamoto Chapter 22: Drugs of Abuse and NeuroAIDS: Opiates Thomas J. Rogers Chapter 23: Cannabinoids Paige S. Katz, Patricia E. Molina Chapter 24: Alcohol and Neurodegeneration Yuri Persidsky, Larisa Goffman, Raghava Potula Part 5: Novel Approaches to Therapy Chapter 25: Cell-Based Drug Delivery for Improving Antiretroviral Therapeutic Outcomes JoEllyn M. McMillan, Howard E. Gendelman Chapter 26: Immunomodulatory Therapeutics for Neurodegenerative Diseases David J. Graber, William F. Hickey Chapter 27: Therapeutic Potential Of Cannabinoids Guy A. Cabral, Melissa Jamerson
