Description
Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters, analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure. Table of Contents: Preface Chapter 1. Basis of Ionic Dysregulation in Cerebral Ischemia Thiruma V. Arumugam, Eitan Okun, and Mark P. Mattson Chapter 2. Why have ionotropic and metabotropic glutamate antagonists failed in stroke therapy? Gianfranco Di Renzo, Giuseppe Pignataro, Lucio Annunziato Chapter 3. Mitochondrial channels as potential target for a pharmacological strategies in brain ischemia. Rosemary H. Milton and Michael R. Duchen Chapter 4. Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke Alexei Verkhratsky Chapter 5. The Na(+)/Ca(2+) Exchanger: a target for therapeutic intervention in cerebral ischemia Lucio Annunziato, Pasquale Molinaro, Agnese Secondo, Anna Pannaccione, Antonella Scorziello, Giuseppe Pignataro, Ornella Cuomo, Rossana Strabella, Francesca Boscia, Alessandra Spinali, Gianfranco Di Renzo Chapter 6. The ‘loop’ Diuretic Drug Bumetanide-sensitive Na+-K+-Cl – Cotransporter in Cerebral Ischemia Dandan Sun Chapter 7. The Na(+)/H(+) exchanger: a target for therapeutic intervention in cerebral ischemia Jin Xue and Gabriel G. Haddad Chapter 8. The Na+/K+-ATPase as a drug target for ischemic stroke Melissa A. Gottron and Donald C. Lo Chapter 9. Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment Giuseppe Pignataro Chapter 10. Role of TRPM7 in Ischemic CNS Injury Michael F. Jackson, Hong-Shuo Sun, Michael Tymianski, and John F. MacDonald Chapter 11. Subtypes of voltage-gated Ca2+ channels and ischemic brain injury Soon-Tae Lee, Daejong Jeon, and Kon Chu Chapter 12. The diverse roles of K+ channels in brain ischemia Hiroaki Misonou and James S. Trimmer Chapter 13. Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke Alessandra Spinali, Giuseppe Pignataro, Gianfranco Di Renzo, Lucio Annunziato
