Description
Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases. Chapter 1 Bovine Spongiform Encephalopathy Gianluigi Zanusso, Salvatore Monaco Chapter 2 Classical and Atypical Scrapie in Sheep and Goats Christine Fast, Martin H. Groschup Chapter 3 Chronic wasting disease and the development of research models Glenn Telling Chapter 4 Sporadic Human Prion Disease Pierluigi Gambetti Chapter 5 Environmentally-acquired Transmissible Spongiform Encephalopathy Paul Brown Chapter 6 Prions in the Environment Shannon L. Bartelt-Hunt, Jason C. Bartz, Samuel E. Saunders Chapter 7 The Spectrum of Tau Pathology in Human Prion Disease Gabor G. Kovacs, Herbert Budka Chapter 8 Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion Alexander H. Peden, Mark W. Head, James W. Ironside Chapter 9 Species Barriers in Prion Disease Suzette A. Priola Chapter 10 Transgenic Mice Modelling Abigail B. Diack, Rona Wilson, Enrico Cancellotti, Barry Bradford, Matthew Bishop, Jean C. Manson Chapter 11 Prion Transmission Studies in Transgenic Mice Qingzhong Kong Chapter 12 Alternative Models of Prion Diseases Pedro Fernandez-Funez, Edward Mlaga-Trillo, Diego E. Rincon-Limas Chapter 13 Diagnosis of Prion Disease: Conventional Approaches Inga Zerr, Joanna Gawinecka, Katharina Stoeck, Maren Breithaupt Chapter 14 Quaking-induced Conversion (QuIC) Assays for the Detection and Diagnosis of Prion Diseases Jason M. Wilham, Christina D. Orr, Sarah Vascellari, Andrew G. Hughson, Byron Caughey Chapter 15 The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context T. Dean Airey, and Neil R. Cashman Chapter 16 Overview on Treatment of Prion Diseases and Decontamination of Prions Richard Knight Chapter 17 Immunomodulation Thomas Wisniewski, Fernando Goi
