Description
Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers – offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialities in the development of new drugs. “Process Chemistry in the Pharmaceutical Industry” highlights new strategies for aggressive drug development programs; provides 12 case studies on agents such as inhibitors and antagonists; illustrates green chemistry and environmentally sound means of synthesizing new medicinal compounds; describes asymmetric synthesis, enantioselectivity, and phase transfer catalysis; explores crystallization and specifications for purity and rigorous new uses of physical/analytical chemistry in refining drugs; reviews the trend toward drugs with wider varieties of heterocyclic functionality, chirality, and greater complex structural features; explicates safety methods and desianalysesperiments; analyzes time-to-market schedules and consequences of acceleration of the development process in the pharmaceutical industry; clarifies the misinterpretation of process chemistry as mere scale-up work; and examines the role of automation in contemporary experimental methodology. Featuring over 1000 references, tables, and illustrations, “Process Chemistry in the Pharmaceutical Industry” is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.
