Description
SECTION I Protein Folding and Quality Control in Drug Discovery Chapter – 1 : Epichaperomes as a gateway to understanding, diagnosing, and treating disease through rebalancing protein-protein interaction networks Chander S. Digwal, Sahil Sharma, Anand R. Santhaseela, Stephen D. Ginsberg, and Gabriela Chiosis, Chapter – 2 : Stability of Steroid Hormone Receptors: The Intersection of Proteostasis and Selective Degradation Zachary J. Gale-Day and Jason E. Gestwicki Chapter – 3: Pharmacological Chaperones; therapeutic potential for diseases resulting from GPCR misfolding Suli-Anne Laurin, Sajjad Ahrari, and Michel Bouvier SECTION II: Protein Degradation and Clearance as Drug Targeting Opportunities Chapter – 4: Exploiting the proteasome for disease treatment: from dynamic architecture to vast functions Gwen R. Buel, Xiuxiu Lu, and Kylie J. Walters Chapter – 5: Targeting the ubiquitination cascade for drug discovery Qi Liu, Gabriel LaPlante, and Wei Zhang Chapter – 6: Understanding, targeting and hijacking autophagy Hongguang Xia, Xiaoyan Xu, Mengxin Zhou, Manke Zhang, and Lingzhi Ye, Chapter – 7: Deubiquitinating enzymes: from undruggable targets to emerging opportunities Ariana Jones, Xiaoxi Liu, Anthony Varca, Lara Doherty, and Sara Buhrlage SECTION III: Redirecting Protein Degradation Processes for Drug Development Chapter – 8: History of IMiDs and protein degradation as a pharmacological modality Junichi Yamamoto, Tomoko Asatsuma-Okumura, Takumi Ito, Yuki Yamaguchi, and Hiroshi Handa Chapter – 9: PROTAC Degraders: Mechanism, Recent Advances and Future Challenges Alessio Ciulli and Oliver Hsia Chapter – 10: Biochemical principles of targeted protein degradation Roman V. Agafonov, Richard W. Deibler, W. Austin Elam, Joe Sahil Patel, and Stewart L. Fisher Chapter – 11: Pharmacology of PROTAC degrader molecules: optimizing for in vivo performance Andy Pike, Sofia Guzzetti, Pablo Morentin Gutierrez, and James S. Scott SECTION IV: Emerging technologies and future opportunities Chapter – 12: Proximity-inducing bifunctional molecules beyond PROTACs Sophia Lai, Ashley E. Modell, and Amit Choudhary Chapter – 13: Strategies for tag-based protein control Behnam Nabet, Nathanael S. Gray, and Fleur M. Ferguson Chapter – 14: Targeted protein degradation in antiviral drug discovery Mlissanne de Wispelaere and Priscilla L. Yang Chapter – 15: Beyond Inhibition: Ligand-Based Pharmacological Exploration as a Strategy Towards New Targets and Modalities Milka Kostic and Lyn H. Jones
