Description
Leading expert physicians and investigators from around the world review the state-of-the-art in the management of squamous cell head and neck cancer, with emphasis on coordinating different treatment modalities. The authors address several surgical issues, including laser-based surgery, larynx preservation approaches, salvage surgery, and neck management after non-operative treatment. They also discuss definitive radiation for larynx cancer, brachytherapy, altered fractionation radiation, intensity modulated radiation therapy, and the importance of tumor hypoxia, as well as the role of chemotherapy in sequential, concurrent, and adjuvant multi-modality treatment schedules. Other topics of special interest include targeted and gene therapies, multimodality management of nasopharyngeal cancer, chemoprevention, toxicity modification, quality of life outcomes, symptom palliation, and epidemiology. Head and Neck Squamous Cell Cancers in the Nonsmoker-Nondrinker Gypsyamber D’Souza and Maura L. Gillison Laryngeal Preservation Surgery Joseph Scharpf and Robert R. Lorenz Laser Surgery for Head and Neck Cancer Lee M. Akst and Marshall Strome The Evolving Role of Neck Dissection in the Era of Organ Preservation Therapy for Head and Neck Squamous Cell Carcinoma Tung T. Trang and Pierre Lavertu Salvage Surgery After Chemoradiation Therapy Walter T. Lee and Ramon M. Esclamado T3-T4 Squamous Cell Carcinoma of the Larynx Treated With Radiation Therapy Alone or Combined With Adjuvant Chemotherapy William M. Mendenhall Role of Brachytherapy in Treatment of Head and Neck Malignancy Ravi A. Shankar, Kenneth S. Hu, and Louis B. Harrison Intensity-Modulated Radiation Therapy in the Management of Head and Neck Cancer Theodore S. Hong, Wolfgang A. Tom, and Paul M. Harari Altered Fractionation: Benefits, Pitfalls With IMRT Dosimetry, and Combined Gains With Molecular Targeting Anesa Ahamad, David I. Rosenthal, and K. Kian Ang The Role of Tumor Hypoxia in Head and Neck Cancer Radiotherapy Quynh-Thu Le, Amato J. Giaccia, and J. Martin Brown Induction Chemotherapy in Head and Neck Cancer: A Critical Review of 25 Years of Clinical Trials Danny Rischin The Evolution of Induction Chemotherapy in Locally Advanced Squamous Cell Cancer of the Head and Neck: The New Paradigm of Sequential Therapy Marshall R. Posner, Lori Wirth, Roy B. Tishler, Charles M. Norris, and Robert I. Haddad Concurrent Chemoradiotherapy: Impact on Survival and Organ Preservation David J. Adelstein Postoperative Treatment of Locally Advanced Head and Neck Cancers Jacques Bernier and Sren M. Bentzen Multimodality Management of Nasopharyngeal Carcinoma Eng-Huat Tan, Swan-Swan Leong,Terence Tan, Kam-Weng Fong, and Joseph Wee Strategies for Protecting Normal Tissue in the Treatment of Head and Neck Cancer David M. Brizel Targeted Therapies in Head and Neck Cancer Tanguy Y. Seiwert and Ezra E. W. Cohen Gene Therapy for Patients With Head and Neck Cancer Andrew Iskander and George H. Yoo Chemoprevention in Head and Neck Cancer Nabil F. Saba and Fadlo R. Khuri Quality of Life Outcomes in Head and Neck Cancer Allen C. Sherman, Ehab Hanna, and Stephanie Simonton Palliation of Head and Neck Cancer Mellar P. Davis Index
