Description
This comprehensive resource details the history, methodology and development of research into psychoneuroimmunology, balancing it with meticulous coverage of both the clinical aspects and practical applications of the subject. * A much-needed reference including overviews of key advances in the field * Discusses how psychoneuroimmunological research is conceived and executed * Includes contributions from a wealth of experts in the field * Forward by Robert Ader and Nicholas Cohen, founders of the discipline * Authoritative and interdisciplinary in scope – integrating biological and behavioral science Alexander Kusnecov is Associate Professor of Psychology at Rutgers University, USA. As well as a number of studies on stress, his work has focused on behavioral conditioning of the immune system, as well as more recently on the neural, endocrine and behavioral consequences of immunologic challenge. Hymie Anisman is a full Professor in the department of Neuroscience, Carleton University, Canada. He holds the distinguished Canada Research Chair in Neuroscience. The principle theme of his research has been the influence of stressors on neurochemical, neuroendocrine and immune systems, and how these influence psychiatric disorders, including depression, anxiety and PTSD. Preface ix Alexander W. Kusnecov and Hymie Anisman Foreword xiii Robert Ader and Nicholas Cohen List of Contributors xvii 1 Basic Principles in Immunology: Relevance for Studies in Psychoneuroimmunology 1 Sarah M. Clark, Kerry C. Michael, Achsah D. Keegan, and Leonardo H. Tonelli 2 Innervation of the Immune System 24 Denise L. Bellinger, Dwight M. Nance, and Dianne Lorton 3 In Vitro and In Vivo Assessment of Immune System Modulation of Brain Function and Neurochemistry 73 Michael O. Poulter and Zul Merali 4 Control and Contributions of the Blood-Brain Barriers to Cytokine Levels in the CNS 88 William A. Banks 5 The Immune-Neuroendocrine Network in Health and Disease 99 Adriana del Rey and Hugo O. Besedovsky 6 Neural Functions of Hematopoietic-derived Cells 120 Noel C. Derecki and Jonathan Kipnis 7 Immunoregulatory Neuropeptides 144 Doina Ganea and Mario Skarica 8 Regulation of Immune Cell Activity by Norepinephrine and Beta2-Adrenergic Receptor Engagement 161 Caroline J. Padro, Jaclyn W. McAlees, and Virginia M. Sanders 9 Immune-to-Brain Communication in Pain: Historical Perspectives, New Directions 176 Peter M. Grace, Linda R. Watkins, and Mark R. Hutchinson 10 Stress and Neuroendocrine-Immune Interaction: A Therapeutic Role for Beta-endorphin 198 Olivia Wynne and Dipak K. Sarkar 11 Assessing Neuroendocrine-Mediated Modulation of Immunity to Infection in Animals: Caveats and Methodological Issues 212 Jodi L. Yorty and Robert H. Bonneau 12 Approaches to Assessing Stressor-Induced Cytokine and Endocrine Changes in Humans 234 Kim Matheson and Hymie Anisman 13 Stress and Immune Function in Humans: A Life-Course Perspective 251 Jan A. Moynihan, Kathi L. Heffner, Mary T. Caserta, and Thomas G. O’Connor 14 Predicting Health: The Role of the Early-Life Environment 266 Luba Sominsky, Adam K. Walker, and Deborah M. Hodgson 15 Microglia and Neurodevelopment: Programming of Cognition throughout the Lifespan 296 Jaclyn M. Schwarz and Staci D. Bilbo 16 Aging and the Immune System 313 Ashley M. Fenn, Angela W. Corona, and Jonathan P. Godbout 17 Peripheral Pro-inflammatory Cytokines and Cognitive Aging: The Role of Metabolic Risk 330 Alvin Lim and Anna Marsland 18 Immune Stimulation and Cognitive Function: Defining the Deficits and Avoiding the Pitfalls 347 Colm Cunningham 19 The Role of NF-kB in Behavioral and Neural Plasticity 365 Elyse M. Mallimo and Alexander W. Kusnecov 20 Inflammatory Roads to Neurodegeneration: A Focus on Parkinson’s and Alzheimer’s Disease 393 Shawn Hayley and Darcy Litteljohn 21 The Psychotic Face of the Immune System: Inflammation and Schizophrenia 411 Urs Meyer 22 Neuroimmune Mechanisms in Autism 425 Veronica M. Miller, Rachael Racine, and Steven S. Zalcman 23 Depression, Inflammation and Tryptophan Metabolism 448 Robert H. McCusker, Annemieke Kavelaars, Cobi J. Heijnen, Robert Dantzer, and Keith W. Kelley 24 An Inflammatory Perspective of Stress and Human Depressive Disorder 469 M.-C. Audet, S. Jacobson-Pick, R. McQuaid, and Hymie Anisman 25 Interaction Between Immune and Energy-Balance Signals in the Regulation of Feeding and Metabolism 488 Alfonso Abizaid, Giamal Luheshi, and Barbara C. Woodside 26 Psychoneuroimmunological Processes in Coronary Artery Disease and Heart Failure 504 Willem J. Kop and Paula M.C. Mommersteeg Index 525
