Description
This clinical casebook covers transfusion medicine theory and its practical implications for the obstetrical hemorrhage patient through the presentation of cases on actively bleeding patients. Each case features a unique clinical scenario involving a bleeding patient and outlines different aspects of safe and effective transfusion support. The cases contain current evidence on the latest topics in the field, such as the use of antifibrinolytic agents and coagulation factor concentrates in the setting of massive obstetrical hemorrhage. In addition to the actively bleeding patient, the casebook includes other important management topics, including the role of plasma exchange in thrombotic microangiopathies during pregnancy; treatment of hyperhemolysis in a patient with hemoglobinopathy; and recommended management of patients with red cell antibodies found on prenatal testing. Other immunohematology topics such as post-natal management of an RhD negative woman for the prevention of hemolytic disease of the newborn due to anti-Rh(D) are included. Written by transfusion medicine, coagulation, obstetrical, and anesthesiology experts, Transfusion Management of the Obstetrical Patient: A Clinical Casebook is a concise yet comprehensive resource for anesthesiologists, obstetricians, pathologists, hematologists, and other practitioners who treat obstetrical hemorrhage patients. Theresa Nester, MD Medical Director of Integrated Transfusion Service Laboratories Program Director, Transfusion Medicine Fellowship Bloodworks Northwest University of Washington Medical Center Department of Laboratory Medicine Seattle, WA USA 1. Obstetrical Management of Postpartum Hemorrhage Michael Dombrowski, Michael Paidas 2. Laboratory Testing and Predictors of Severe Postpartum Hemorrhage Evelyn Lockhart 3. Component Therapy in Obstetric Hemorrhage Joseph Griggs 4. Evidence for 1:1:1 Transfusion Support and Importance of a Hemorrhage Protocol Mark Fung, Sara Harm 5. Evidence for/against Administration of Anti-fibrinolytic Agents during an Obstetrical Hemorrhage Kerry L. O’Brien 6. Evidence for/against Administration of Fibrinogen Concentrate and Coagulation Factor Concentrate during an Obstetrical Hemorrhage Michael Dombrowski, Michael Paidas 7. Recommendations on Blood Recovery in Obstetrics Gerhardt Konig 8. Thrombocytopenia in Pregnancy Thomas G. DeLoughery 9. Von Willebrand Disease in Pregnancy Thomas G. DeLoughery 10. Platelet Count and Neuraxial Anesthesia Cathleen Peterson-Layne, Beth R. Burton 11. ABO Compatibility Theresa Nester 12. RhD Compatibility Jessica Poisson 13. Other Rh Antibodies that Can Impact Transfusion Jessica Poisson 14. Importance of Getting a Sample for ABO Type Early in a Resuscitation Ashok Nambiar 15. Risks of Giving Uncrossmatched Red Cells Ashok Nambiar 16. Management of Thrombotic Microangiopathies in Pregnancy Jeffrey L. Wintersa, Vesna D. Garovicb, Layan Alrahmanic, Kristina A. Davis 17. Hyperhemolysis Syndrome in a Pregnant Woman with Sickle Cell Anemia Henry Hilt, Oyebimpe Adesina 18. Fetal and Neonatal Alloimmune Thrombocytopenia Justin Juskewitch, Jeffrey Winters 19. Weak D in Pregnancy Meghan Delaney 20. Testing Algorithm for Rh Immune Globulin Dosing in the Post-natal RhD-negative Mother Theresa Nester 21. Pre-transfusion Testing in Women with High Bleeding Risk Requiring Prolonged Hospitalization Theresa Nester, Katherine L. Eastwood 22. Warm Autoantibodies During Pregnancy Chakri Gavva 23. Hemolytic Disease of the Fetus and Newborn/Selection of Red Cells for Intrauterine Transfusion Brian Gorospe, Nabiha Huq Saifee 24. Maternal Red Cell Alloantibody Directed Against a High Incidence Antigen Theresa Nester
