Description
With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targetedand thus more effective. Table of Contents: TCNS Volume 8 Astrocytoma Chapter 1. astrocytoma cell line: role of brain natriuretic peptide chapter 2. malignant brain astrocytomas: extent of resection affects survival medulloblastoma chapter 3. medulloblastoma: classification (a review) chapter 4. medulloblastomas: clinically important microrna genes chapter 5. medulloblastoma: role of otx2 transcription factors chapter 6. molecular mechanisms of chemoresistance in medulloblastoma chapter 7. extraneural metastasis in medulloblastoma Chapter 8. Medulloblastoma: Therapy with Bortezomib/Tumor Necrosis factor-related apoptosis-inducing ligand chapter 9.standard-risk medulloblastoma: hyperfractionated radiotherapy retinoblastoma chapter 10. retinoma and retinoblastoma: genomic hybridisation chapter 11. cell cycle control by ataxia telangiectasia mutated protein through regulating retinoblastoma protein phosphorylation chapter 12. role of survivin in retinoblastoma: diagnosis and prognosis chapter 13. retinoblastoma: the role of epigenetics chapter 14. retinoblastoma: disease, diagnosis, therapy and management chapter 15. long-term survivors of retinoblastoma: risk of increased second malignancy chapter 16. new cancers among long-term survivors of retinoblastoma chordoma chapter 17. chordoma: role of cam5.2 chapter 18. chordomas and chondrosarcomas: treatment with particle radiotherapy chapter 19. skull base chordomas: endonasal endoscopic transclival approach craniopharyngioma chapter 20. craniopharyngioma: comparison between supra-orbital versus endonasal keyhole approaches chapter 21. the expanded endoscopic endonasal approach for primary and recurrent craniopharyngiomas chapter 22. craniopharyngioma: the role of radiation chapter 23. cystic craniopharyngiomas: intratumoral bleomycin therapy oligodendroglioma chapter 24. anaplastic oligodendroglioma metastasized to extraneural sites chapter 25. recurrent oligodendroglioma: treatment with bevacizumab ependymoma chapter 26. ependymoma: an overview chapter 27. ependymomas: prognosis based on genetic aberrations chapter 28. aberrant dna methylation in ependymomas chapter 29. progressively metastasizing ependymoma: genomic aberrations chapter 30. extradural ependymoma: diagnosis using magnetic resonance imaging chapter 31. primary malignant ependymoma of the abdominal cavity: diagnosis chapter 32. atypical histologic features and patterns of malignant evolution in tanycytic ependymoma chapter 33. intracranial ependymoma: role for chemotherapy.
