Description
Aiming toward improvement in the safety, efficiency, and specificity of viral vectors for neurobiological research and clinical applications, Viral Vector Approaches in Neurobiology and Brain Diseases covers key aspects related to the use of viral vectors in neuroscience, with a major emphasis on basic mechanisms of synaptic plasticity, learning, and memory, as well as molecular neuropharmacology and experimental animal models of brain disorders. The volume begins by delving into features of the viral vectors currently available in neuroscience and their production methods, and it then continues onward to examples of successful applications of viral vector technology to psychiatric and memory research, current applications of viral vector technology in the context of neurological disorders, as well as various cutting-edge applications of viral vector technology to neuroscience, including optogenetics. Written for the Neuromethods series, the chapters of this book contain the kind of detailed description and implementation advice that promotes successful, repeatable results. Practical and up to date, Viral Vector Approaches in Neurobiology and Brain Diseases will be useful not only to neurobiologists wishing to routinely use viral vectors in the laboratory but also to experienced scientists needing detailed new protocols for a variety of experimental applications. Part I: Types of Viral Vectors in Neuroscience Research 1. Lentiviral Vectors as Research Tools in Neurobiology: Design and Production Alessandro Papale and Riccardo Brambilla 2. Recombinant Adenovirus in Neurobiology Qian Li and Tong-Chuan He 3. Adeno-Associated Virus-Based Vectors Nathalie Dutheil and Erwan Bezard 4. Herpes Simplex Virus 1 (HSV-1)-Based Vectors Aldo Pourchet, Matias E. Melendez, Anna Greco, and Alberto L. Epstein 5. Alphavirus-Based Vectors Kenneth Lundstrom Part II: Viral Vectors in Memory Research and Psychiatric Diseases 6. Viral Vectors to Study Synaptic Function Hlne Marie 7. Using Viral Vectors to Study the Memory Trace in Mice Asim J. Rashid, Chen Yan, and Sheena A. Josselyn 8. Development of Cell-Type Specific Viral Vectors to Tease Apart the Neural Circuitry that Contributes to Drug Addiction Susan M. Ferguson and John F. Neumaier 9. Using Viral-Mediated Gene Transfer to Study Depressive-Like Behavior Amy R. Furay and John F. Neumaier Part III: Viral Vectors in Neurological Disorders 10. Gene Therapy for Parkinson’s Disease Erika Elgstrand Wettergren, Luis Quintino, Giuseppe Manfr, and Cecilia Lundberg 11. Lentiviral Vectors in Huntington’s Disease Research and Therapy Aurlie Delzor, Nolle Dufour, and Nicole Dglon 12. Application of Viral Vectors to Motor Neuron Disorders Elisabeth Dirren and Bernard L. Schneider Part IV: Applications of Viral Vector Technology to Neuroscience Research 13. In Vivo Gene Silencing by Virally Delivered MicroRNA Eugenia V. Gurevich, Mohamed R. Ahmed, and Yonatan Carl 14. Viral Manipulation of Neural Stem/Precursor Cells Nunzio Iraci, Giulia Elisabetta Tyzack, Chiara Cossetti, Clara Alfaro-Cervello, and Stefano Pluchino 15. Viral Vector-Based Techniques for Optogenetic Modulation In Vivo Mathias Mahn, Shiri Ron, and Ofer Yizhar 16. Viral Vectors for Optogenetics of Hypothalamic Neuropeptides H. Sophie Knobloch, Alexander Charlet, Ron Stoop, and Valery Grinevich 17. Viral Vectors in Primate Research: Examples from Parkinson’s Disease Research Grgory Porras, Benjamin Dehay, and Erwan Bezard
