Description
This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences. Historical Overview. -Tutorial on Transmembrane Currents and Ion Channels. -Structural and Functional Properties of Ion Channels. -Atomic Structures of Ion Channels. -Gramicidin Channels. -Potassium Channels. -Voltage-Gated Channels. -ClC Chloride Channels. -Sodium Channels. -Calcium Channels. -Mechano-Sensitive Channels. -Ligand-Gated Channels. -Dynamics of Ion Channels. -Poisson-Nernst-Planck Theory. -Semi-Microscopic Monte Carlo Method. -Brownian Dynamics. -Molecular Dynamics. -Emerging Technologies. -Microchip Technology in Ion Channel Research. -Biosensors. -Signal Processing with Hidden Markov Models.
