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Frontmatter — Preface — Bicentennial of the first vaccination by Edward Jenner / Kaufmann, Stefan H.E. — Contents — 1. The Need for New Vaccines — 1.1. Vaccines as Evolutionary Tools: The Virulence-Antigen Strategy / Ewald, Paul W. — 1.2. Economic Perspectives on Vaccine Needs / Ashley, Robert V. / Murray, Christopher J. L. — 1.3. Future Immunization Strategies – Considerations from the Public Health View / Dittmann, Sieghart — 1.4. The New Pertussis Vaccines / Klein, David L. / Heilman, Carole — 2. General Principles of Immunology — 2.1. Basic Principles of Immunity Against Intracellular Bacteria and Protozoa / Szalay, Gudrun / Kaufmann, Stefan H. E. — 2.2. Viral Immunity and Vaccine Strategies / Woodland, David L. / Cole, Geoffrey A. / Doherty, Peter C. — 2.3. Broadly Reactive HLA Restricted Cell Epitopes and Their Implications for Vaccine Design / Sidney, John / Kubo, Ralph T. / Wentworth, Peggy A. / Alexander, Jeff / Chesnut, Robert W. / Grey, Howard M. / Sette, Alessandro — 2.4. Quantitative Considerations in the Design of Vaccination Strategies Against Pathogens Uniquely Susceptible to Cell-Mediated Attack / Bretscher, Peter — 2.5. The Impact of the Type 1 and Type 2 Helper Cell Concept on Novel Vaccine Design with Emphasis on Protection Against Leishmania Parasites / Bogdan, Christian / Rllinghoff, Martin — 3. General Principles of Vaccinology — 3.1. Modern Adjuvants. Functional Aspects / Morein, Bror / Lvgren-Bengtsson, Karin / Cox, John — 3.2. Biodegradable Microspheres as Vehicles for Antigens / Kersten, Gideon F.A. / Gander, Bruno — 3.3. Peptide Based Vaccines / Schild, Hansjrg / Rammensee, Hans-Georg — 3.4. Recombinant Bacteria as Vaccine Carriers of Heterologous Antigens / Hormaeche, Carlos E. / Khan, C. M. Anjam — 3.5. Genetic Detoxification of Bacterial Toxins / Rappuoli, Rino / Pizza, Mariagrazia — 3.6. Recombinant Virus as Vaccination Carrier of Heterologous Antigens / Perkus, Marion E. / Paoletti, Enzo — 3.7. Naked DNA Vaccination / Shiver, John W. / Ulmer, Jeffrey B. / Donnelly, John J. / Liu, Margaret A. — 3.8. Oral Vaccination, Mucosal Immunity and Oral Tolerance with Special Reference to Cholera Toxin / Holmgren, Jan / Czerkinsky, Cecil / Sun, Jia-Bin / Svennerholm, Ann-Mari — 4. Specific Vaccination Strategies — 4.1. Helicobacter pylori: Pathogenic Determinants and Strategies for Vaccine Design / Ghiara, Paolo / Covacci, Antonello / Telford, John L. / Rappuoli, Rino — 4.2. Malaria Vaccination / Patarroyo, Manuel E. / Amador, Roberto — 4.3. Vaccination Against Schistosomiasis: Concepts and Strategies / Riveau, Gilles J. / Capron, Andr — 4.4. AIDS Vaccination / Norley, Stephen / Kurth, Reinhard — 4.5. Vaccination Therapy Against Autoimmune Diseases / Cohen, Irun R. / Mor, Felix — Contributors — Index

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