Description
New principles for the treatment of diabetes are described in this volume. Experts present experimental and clinical data on treatment with acarbose, an alpha-glucosidase inhibitor that delays absorption of fast carbohydrates. Toxicologic, pharmacologic and metabolic effects of acarbose are discussed. A concluding section on the future aspects of alpha-glucosidase inhibition offers a fair assessment of therapeutic possibilities. Experimental Data on Acarbose I.- Toxicology of Acarbose, with Special Reference to Long-Term Carcinogenicity Studies.- Discussion.- The Disposition and Pharmacokinetics of Acarbose in Man.- Discussion.- Experimental Data on Acarbose II.- The Pharmacological Rationale of Diabetes Mellitus Therapy with Acarbose.- Discussion.- Pharmacodynamics of Acarbose: Clinical Investigations.- Discussion.- Posters.- Comparative Effects of Acarbose on Glycemia, Weight Gain, and Serum Lipids in Adult Male and Female Diabetic Wistar Fatty Rats.- Effects of Low-Dose Acarbose on Glycemia, Adiposity, and Cholesterolemia in Obese and Obese Non-Insulin-Dependent Diabetic Corpulant Rats.- A Preclinical Study on the Effects of Acarbose on Mice Rendered Obese with Gold Thioglucose.- Enhancement of Insulin Binding and Glucose Transport by Acarbose in Adipocytes of Zucker Rats.- Treatment of Streptozotocin-Diabetic Rats with Acarbose: Influence on Metabolism and Heart Function.- Effects of Acarbose on Cardiac and Hepatic Metabolism in Diabetic Rats.- Effects of Acarbose on Experimental Diabetic Nephropathy, Metabolic Control, and Intestinal Glycosidase Activity in Normal and Genetically Diabetic Mice.- The Effectiveness of Acarbose in the Reduction of Diabetic Symptoms and Neuropathic Complications in an NIDDM Animal Model.- Effects of Acarbose on the Hormonal and Metabolic Response to the Simultaneous Ingestion of Sucrose and Ethanol.- Effects of Acarbose on Serum Lipids and Lipoproteins in Healthy Individuals During Prolonged Administration of a Fiber-Free Diet.- Lower Triglyceride Production with Carbohydrate-Rich Diets During Treatment with Acarbose.- Long-Term Metabolic Effects of Acarbose in Healthy Young Men.- Mode of Action of the ?-Glucosidase Inhibitor Acarbose in the Small Bowel: A Perfusion Study in Man.- Effect of Acarbose in Fecal Short-Chain Fatty Acid Excretion in Man.- Effect of Acarbose on Colonic Nitrogen Metabolism in Man.- The Influence of Acarbose Dosage Scheme on Intestinal Symptoms and Intestinal Transit Time in Healthy Volunteers.- The Development of a Method for Measuring Starch Absorption and its Alteration by ?-Glucosidase Inhibitors.- Acarbose in NIDDM.- Acarbose in Non-Insulin-Dependent Diabetes Mellitus: Short-Term Studies in Combination with Oral Agents.- Acarbose in Non-Insulin-Dependent Diabetes – Long-Term Studies in Combination with Oral Agents.- Discussion.- Acarbose Monotherapy in the Treatment of Non-Insulin-Dependent Diabetes Mellitus.- Discussion.- Posters.- Acarbose Treatment of NIDDM: Multiclinic Trial for Dose Finding.- Metabolic Effects of Acarbose in Normal and NIDDM Subjects.- Efficacy and Tolerability of a 3-Month Treatment with Acarbose in Type II Diabetic Outpatients Treated with a High Dose of Sulfonylurea.- Metabolic Control in Type II Diabetes with Long-Term Acarbose Therapy: A Double-Blind Study.- Clinical Trial to Investigate the Efficacy and Tolerability of Acarbose in Type II Diabetic Patients Treated with Diet Alone.- Comparison of the Action of an ?-Glucosidase Inhibitor (Acarbose) and a Sulfonylurea Preparation (Glisoexpide) in Non-Insulin-Dependent Diabetics.- Efficacy of the Glucosidase Inhibitor Acarbose Compared to the Sylfonylurea Glisoexpide on Metabolic Control in Diet-Treated Type II Diabetics.- Multicenter Clinical Trial Up to 15 Months: Efficacy and Tolerability of Acarbose in Glibenclamide-Treated Type II Diabetics with Secondary Sulfonylurea Failure Versus Glibenclamide Therapy Alone.- Acarbose Does not Affect Glibenclamide Pharmacokinetics in Type II Diabetic Patients.- Effect of Acarbose in Type II Diabetics Treated with Diet Alone, with Diet, and with Sulfonylurea, Diet, and Insulin.- The Long-Term Effects of Acarbose on Type II Diabetics on Diet or Oral Agents.- Long-Term Effects of Acarbose Treatment on Postprandial Glucose, Pancreatic and Gut Hormone Responses and Fasting Serum Lipids in Non-Insulin-Dependent Diabetics on Sulfonylureas.- Acarbose in the Treatment of NIDDM Patients with Hyperlipemia.- Effectiveness and Tolerability of the ?-Glucosidase Inhibitor Acarbose in NIDDM Patients with Elevated Liver Enzyme Activity.- Effect of Acarbose on Blood Glucose and Insulin Response to a Sucrose Load in Subjects with Reactive Hypoglycemia.- Relapse-Reducing Effects of Acarbose After Weight Reduction in Severely Obese Subjects.- Acarbose in IDDM.- Acarbose Treatment in Insulin-Dependent (Type I) Diabetes Mellitus.- Discussion.- Acarbose Treatment and Sulfonylurea Secondary Failure.- Discussion.- Clinical Studies with Acarbose for the Control of Hyperglycemia which is the Major Pathogenetic Factor of the Complications of Diabetes Mellitus.- Discussion.- Posters.- Inhibition of ?-Glucosidase by Acarbose as an Additional tool for Glycemia Control in Insulin-Dependent Diabetics on Conventional Insulin Therapy.- Acarbose in Insulin-Dependent Diabetes Mellitus: Efficacy and Tolerance.- Nonrandomized Follow-up Study with Acarbose Treatment and Pre- and Post-treatment with Placebo in Type I Diabetic Children.- Effects of Acarbose on Glycemic Control in IDDM under Feedback Control with Artificial Endocrine Pancreas.- Effects of Sucrose Meal on Insulin Requirement in IDDM and its Modulation by Acarbose.- Effect of Acarbose on Insulin Sensitivity and Liver Uptake in Patients with Type I Diabetes.- Comparative Metabolic Availability of Glucose and Sucrose and the Effect of Acarbose on Sucrose Utilization During Exercise in Type I Diabetic Patients.- Acarbose Treatment in Insulin-Dependent Diabetics.- Panel Discussion: Future Aspects of ?-Glucosidase Inhibition.- Author Index.
