Description
rthanitwas20yearsago,inpartbecause inthe last 2 decades a number of chronic diseases of unknown etiology (e.g. gastric ulcers, Kaposi’s sarcoma, hepatocellular carcinoma) have been ascribedtoinfectiouscauses. Preface. 1. Introduction and History. 1.1. A brief history of the viral hypothesis. 2. Fundamentals of Viral Infections and Immune Responses in Humans. 2.1. A primer on general virology. 2.2. Immune response to viral infections. 2.3. Persistent viral infections. 3. Encephalitis and Schizophrenia. 3.1. Viruses and schizophrenia: a plurality of theories. 3.2. Psychosis in viral encephalitis. 3.3. The validity gap for the encephalitis connection. 3.4. Borna diseases virus. 3.5. Viruses in other psychiatric diseases. 4. Epidemiological Evidence. 4.1. Epidemiological studies of the viral hypothesis. 4.2. Seroepidemiological studies. 4.3. Immune alterations in schizophrenia. 5. The Role of Viral Infections During Neurodevelopment. 5.1. Brain development. 5.2. Immunology of the maternal-fetal unit. 5.3. Viro-developmental hypothesis. 5.4. Epidemiological studies of perinatal infections in adult schizophrenia. 6. Models and Mechanisms. 6.1. Specific models. 6.2. A history lesson from oncology concerning the viral hypothesis. 6.3. What a viral etiology of schizophrenia does not mean. 6.4. Conclusion. Index.
