Description
An exploration of the nature of dopamine-glutamate interactions in the basal ganglia from receptor molecules to complex behaviors, this volume reviews basic anatomy, discusses the subtypes and signaling pathways of the dopamine and glutamate receptors expressed in the basal ganglia, and their interaction down to the molecular level. Coverage includes endogenous and exogenous modulators of dopamine-glutamate interactions and the implications of these interactions, measuring the key basal ganglia functions at the physiological and behavioral level. It also examines the concept that compromised dopamine-glutamate interactions may underpin basal ganglia disorders. Metabotropic Glutamate ReceptorDopamine Interactions in the Basal Ganglia Motor Circuit. Ionotropic Glutamate Receptors in the Basal Ganglia. Dopamine Receptors and their Interactions with NMDA Receptors. Synaptic Triad in the Neostriatum: Dopamine, Glutamate, and the MSN. Dopaminergic Modulation of Glutamatergic Synaptic Plasticity in Striatal Circuits: New Insights from BAC-Transgenic Mice. Striatal AcetylcholineDopamine Crosstalk and the DorsalVentral Divide. Electrophysiology of the Corticostriatal Network In Vivo. Functional Organization of the Midbrain Substantia Nigra. Striatal Dopamine and Glutamate in Action: The Generation and Modification of Adaptive Behavior. Impaired DopamineGlutamate Receptor Interactions in Some Neurological Disorders. Index.
