Description
List of Contributors Preface CHAPTER 1. Overview of Drug Transporter Families Guofeng You and Marilyn E. Morris CHAPTER 2. Organic Cation and Zwitterion Transporters Megan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and KathleenM. Giacomini CHAPTER 3. Multidrug and Toxin Extrusion Proteins Lauren M. Aleksunes, Victoria Woo, and Melanie S. Joy CHAPTER 4. Organic Anion Transporters (OATs) Jeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. Nigam CHAPTER 5. Organic Anion Transporting Polypeptides OATP Rommel G. Tirona and Richard B. Kim CHAPTER 6. Mammalian Oligopeptide Transporters Stephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp. CHAPTER 7. Monocarboxylic Acid Transporters Marilyn E. Morris and Nisha V. Kwatra CHAPTER 8. The Nucleoside Transporters CNTs and ENTs Raj Govindarajan, Antonio Lpez Quiones, and Joanne Wang CHAPTER 9. Bile Acid Transporters Ebehiremen N. Ayewoh and Peter W. Swaan CHAPTER 10. The P-glycoprotein Multidrug Transporter Andaleeb Sajid, Sabrina Lusvarghi and Suresh V. Ambudkar CHAPTER 11. Multidrug Resistance Proteins of the ABCC Subfamily Anne T. Nies and Franziska Klein CHAPTER 12. ABCG2, the Breast Cancer Resistance Protein (BCRP) Robert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. Bates CHAPTER 13. Drug Transport in the Liver Noora Sjstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. Brouwer CHAPTER 14. Drug Transport in the Brain Vishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina Bendayan CHAPTER 15. Drug Transport in the Kidney Douglas H. Sweet CHAPTER 16. Drug transporters in the human intestine Stefan Oswald CHAPTER 17. Drug Transport in the Placenta Qingcheng Mao, Vadivel Ganapathy, and Jashvant D. Unadkat CHAPTER 18. Polymorphisms of drug transporters and clinical relevance Tore B. Stage and Deanna L. Kroetz CHAPTER 19. Ontogeny of Drug Transporters Melanie A. Felmlee and Qing Zhang CHAPTER 20. Experimental Approaches for Studying Drug Transporters Yusuke Masuo, Azusa Futatsugi, and Yukio Kato CHAPTER 21. Transporters mediated drug disposition – Physiochemistry and in silico approaches Manthena V. S. Varma, Ayman El-Kattan, and Yurong Lai CHAPTER 22. In vitro-in vivo scale-up of drug transport activities Kazuya Maeda and Yuichi Sugiyama CHAPTER 23. Application of Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling Comprising Transporters: Delineating the Role of Various Factors in Drug Disposition and Toxicity Matthew D. Harwood, Amin Rostami-Hodjegan, and Sibylle Neuhoff CHAPTER 24. Transporters as therapeutic targets in human diseases Robert S. Jones and Eugene C. Chen CHAPTER 25. Diet/Nutrient Interactions with Drug Transporters Marilyn E. Morris and Tianjing Ren Index
