Description
Having been a fairly dormant specialty for many decades, in recent years there has been a remarkable increase in activity in Neuro-oncology from basic science through to the clinics. Reflecting this there have been considerable advancements in the understanding of the biology of CNS malignancies which have infirmed the development of many novel and successful therapies. This work aims to bring together the scattered literature on the new concepts in neuro-oncology for the benefit of those in the field. The book moves from concepts in the scientific basis of neuro-oncology, through to modelling techniques and finishing on the translation into clinical practice. Colin Watts is a Clinician Scientist and Honorary Consultant Neurosurgeon at the Department of Clinical Neurosciences, Cambridge Centre for Brain Repair and Neurosurgery Unit, Cambridge University. Part I Scientific Foundations 1. Classification of Gliomas Pieter Wesseling 2. Epigenetics and Brain Cancer Davide Sciuscio and Monika E. Hegi 3. Astrocyte Differentiation from Oligodendrocyte Precursors Akiko Nishiyama 4. Stem Cells and Brain Cancer Sara G.M. Piccirillo Part II Models of Brain Cancer 5. In Vitro Models of Brain Cancer David J. Ryan and Colin Watts 6. Mouse Models of Glioma Pathogenesis: History and State of the Art Sebastian Brandner 7. The Application of Novel Ionising Radiation Species for Glioblastoma Raj Jena 8. Advances in Imaging Brain Cancer Stephen J. Price and Adam D. Waldman Part III Emerging Concepts in Clinical Practice 9. Surgical Management of Glial Cancers Walter Stummer 10. Radiation Oncology in Brain Cancer Susan C. Short 11. Managing the Elderly Patient Anthony J. Chalmers and Kathryn Graham 12. Brain Tumour Presentation in Children and Young People David A. Walker and Sophie Wilne 13. How Can We Improve Clinical Trial Recruitment in Neuro-Oncology? Sarah Jefferies
